Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-DnaT |
Location | 31479..32001 | Replicon | plasmid p803Rt_IncY |
Accession | NZ_CP080068 | ||
Organism | Escherichia coli strain 19SZHZ803Rt |
Toxin (Protein)
Gene name | relE | Uniprot ID | G3CAN5 |
Locus tag | KZO14_RS23165 | Protein ID | WP_000220560.1 |
Coordinates | 31720..32001 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | G3CAG1 |
Locus tag | KZO14_RS23160 | Protein ID | WP_000121743.1 |
Coordinates | 31479..31730 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZO14_RS23135 (KZO14_23120) | 27150..27431 | + | 282 | WP_001185482.1 | hypothetical protein | - |
KZO14_RS23140 (KZO14_23125) | 27456..28433 | + | 978 | WP_024245156.1 | hypothetical protein | - |
KZO14_RS23145 (KZO14_23130) | 28430..28786 | - | 357 | WP_000456533.1 | DNA distortion polypeptide 3 | - |
KZO14_RS23150 (KZO14_23135) | 28923..29369 | - | 447 | Protein_30 | hypothetical protein | - |
KZO14_RS23155 (KZO14_23140) | 29409..30245 | - | 837 | WP_001050931.1 | RepB family plasmid replication initiator protein | - |
KZO14_RS23160 (KZO14_23145) | 31479..31730 | + | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
KZO14_RS23165 (KZO14_23150) | 31720..32001 | + | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KZO14_RS23170 (KZO14_23155) | 32076..32773 | + | 698 | WP_223417112.1 | IS1-like element IS1A family transposase | - |
KZO14_RS23175 (KZO14_23160) | 32895..33092 | + | 198 | WP_000844102.1 | hypothetical protein | - |
KZO14_RS23180 (KZO14_23165) | 33112..33384 | - | 273 | Protein_36 | IS1 family transposase | - |
KZO14_RS23185 (KZO14_23170) | 33478..34911 | + | 1434 | WP_001288435.1 | DNA cytosine methyltransferase | - |
KZO14_RS23190 (KZO14_23175) | 34945..36159 | - | 1215 | WP_001532073.1 | type II site-specific deoxyribonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | qnrS1 | - | 1..39170 | 39170 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11005.83 Da Isoelectric Point: 10.5938
>T210616 WP_000220560.1 NZ_CP080068:31720-32001 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
Download Length: 282 bp
>T210616 NZ_CP104579:c3376243-3375674 [Pseudomonas oleovorans]
ATGTTCAAGCCGCAGCTGGTGACTTTGCAACGTGGCGCTCTGCGCCTGGAACCGCTCTCTGACGCCGATATCCCCGCGCT
GGTGGCGCTGGCCGAAGCCAATCGCGAGGAGCTGCTGTACATGAGCGGTACTCAGCGACTGGACTGGTACCGCAGCGCCC
TGGCCGATATGCGCGAGCAGCGGGCACTGCCGTTCGTCATTCGTCTGGGTAACGAGTGGGTAGGCACCACCCGCTTCGCC
GACTTCATGAACCCCCTGCCGGCCTGTGAAATCGGCTGGACCTGGCTCGACCGCAATCAGCATGGCAGCGGGTTGAACAC
CAGCATCAAGTACCTGATGCTCAAGCACGCTTTCGAAAATTGGGGCATGGTTCGCGTGCAACTGAAAACTGCCGCCAGCA
ACCTGCGTTCGCAACGCGCCATCGAGAAGCTTGGTGCCGTTCGTGAAGGGTTGCTGCGCAACCATCGCCGTCTGGCTGAT
GGCCGACTCGATGACACCGTGCTGTACAGCATCACCGACCTGGAATGGCCGGCGCTGCGTGGGGCCATGGAGGCGGGCTT
CAACGCCTGA
ATGTTCAAGCCGCAGCTGGTGACTTTGCAACGTGGCGCTCTGCGCCTGGAACCGCTCTCTGACGCCGATATCCCCGCGCT
GGTGGCGCTGGCCGAAGCCAATCGCGAGGAGCTGCTGTACATGAGCGGTACTCAGCGACTGGACTGGTACCGCAGCGCCC
TGGCCGATATGCGCGAGCAGCGGGCACTGCCGTTCGTCATTCGTCTGGGTAACGAGTGGGTAGGCACCACCCGCTTCGCC
GACTTCATGAACCCCCTGCCGGCCTGTGAAATCGGCTGGACCTGGCTCGACCGCAATCAGCATGGCAGCGGGTTGAACAC
CAGCATCAAGTACCTGATGCTCAAGCACGCTTTCGAAAATTGGGGCATGGTTCGCGTGCAACTGAAAACTGCCGCCAGCA
ACCTGCGTTCGCAACGCGCCATCGAGAAGCTTGGTGCCGTTCGTGAAGGGTTGCTGCGCAACCATCGCCGTCTGGCTGAT
GGCCGACTCGATGACACCGTGCTGTACAGCATCACCGACCTGGAATGGCCGGCGCTGCGTGGGGCCATGGAGGCGGGCTT
CAACGCCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT210616 WP_000121743.1 NZ_CP080068:31479-31730 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT210616 NZ_CP104579:c3375668-3374841 [Pseudomonas oleovorans]
ATGCACAGTCGCGAGCAGACCCGCTTCTGGCAAGCTTCCGCATTGAGCGGCGTCGAGCTGTTGCAGGCGCGCTACCTTGA
ACAGCGCTTCGCGCCCCACGTGCATGAAGGTTTCGTGTTCACCGTGATCGAGCATGGCGCCCAGCGCTTTCGTCATCGCG
GTTGTGATCATCTGGCCCCACAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGCTCCAAGGCGCACGAA
GACGGTTGGCGCTATCGCGGTTTCTATCCCGACAACGCCCAGGTTCTGGGGGCGCTGCAGGAGCTGGGTCTGGCCAAGGC
TGGCATGCCGTCGTTTGCCTTCAGTGTGCTGCATGATCCACGTTTGCACGCGGCCTTTCTGCAACTGCACCAACTGCTCG
AGGGCGGCGCCGAGGCACTGCAGCAGCAACTGGCCTGGCGTGAGGCAATGCTGCTGCTGTTTCAGCACCATGCGCAGCTT
GCCGAACCACCTGCGCCTGGGCGTGAGCCCTGGGCAGTGGCTTGTGCCAAGCAGATGCTCGCCGAGCGGCTGATCGAGCC
GCCCTCGCTGGAGGAACTGGCGGCTGCGGTCAATCTTTCACCGTTTCATTTCGCTCGAGTGTTCCGCCGCGAGACCGGCT
TGCCACCGCATGCCTGGCTCAAGCAACGGCGCCTGGAGCAGGCGCGGGCGTTGCTCAAGACGGGCTGCACGGCGGTCGCT
GTGGCCATGCAGTTGGGCTTCGCTGATCAGAGCCACTTGTCGCGACAGTTCAAGCAGGTTTATGGCGTGAGCCCTGGCGA
ATATCGCAGCGCAGTGGCACGAAGCTGA
ATGCACAGTCGCGAGCAGACCCGCTTCTGGCAAGCTTCCGCATTGAGCGGCGTCGAGCTGTTGCAGGCGCGCTACCTTGA
ACAGCGCTTCGCGCCCCACGTGCATGAAGGTTTCGTGTTCACCGTGATCGAGCATGGCGCCCAGCGCTTTCGTCATCGCG
GTTGTGATCATCTGGCCCCACAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGCTCCAAGGCGCACGAA
GACGGTTGGCGCTATCGCGGTTTCTATCCCGACAACGCCCAGGTTCTGGGGGCGCTGCAGGAGCTGGGTCTGGCCAAGGC
TGGCATGCCGTCGTTTGCCTTCAGTGTGCTGCATGATCCACGTTTGCACGCGGCCTTTCTGCAACTGCACCAACTGCTCG
AGGGCGGCGCCGAGGCACTGCAGCAGCAACTGGCCTGGCGTGAGGCAATGCTGCTGCTGTTTCAGCACCATGCGCAGCTT
GCCGAACCACCTGCGCCTGGGCGTGAGCCCTGGGCAGTGGCTTGTGCCAAGCAGATGCTCGCCGAGCGGCTGATCGAGCC
GCCCTCGCTGGAGGAACTGGCGGCTGCGGTCAATCTTTCACCGTTTCATTTCGCTCGAGTGTTCCGCCGCGAGACCGGCT
TGCCACCGCATGCCTGGCTCAAGCAACGGCGCCTGGAGCAGGCGCGGGCGTTGCTCAAGACGGGCTGCACGGCGGTCGCT
GTGGCCATGCAGTTGGGCTTCGCTGATCAGAGCCACTTGTCGCGACAGTTCAAGCAGGTTTATGGCGTGAGCCCTGGCGA
ATATCGCAGCGCAGTGGCACGAAGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G3CAN5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S5I301 |