Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 31479..32001 Replicon plasmid p803Rt_IncY
Accession NZ_CP080068
Organism Escherichia coli strain 19SZHZ803Rt

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag KZO14_RS23165 Protein ID WP_000220560.1
Coordinates 31720..32001 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KZO14_RS23160 Protein ID WP_000121743.1
Coordinates 31479..31730 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO14_RS23135 (KZO14_23120) 27150..27431 + 282 WP_001185482.1 hypothetical protein -
KZO14_RS23140 (KZO14_23125) 27456..28433 + 978 WP_024245156.1 hypothetical protein -
KZO14_RS23145 (KZO14_23130) 28430..28786 - 357 WP_000456533.1 DNA distortion polypeptide 3 -
KZO14_RS23150 (KZO14_23135) 28923..29369 - 447 Protein_30 hypothetical protein -
KZO14_RS23155 (KZO14_23140) 29409..30245 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
KZO14_RS23160 (KZO14_23145) 31479..31730 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KZO14_RS23165 (KZO14_23150) 31720..32001 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZO14_RS23170 (KZO14_23155) 32076..32773 + 698 WP_223417112.1 IS1-like element IS1A family transposase -
KZO14_RS23175 (KZO14_23160) 32895..33092 + 198 WP_000844102.1 hypothetical protein -
KZO14_RS23180 (KZO14_23165) 33112..33384 - 273 Protein_36 IS1 family transposase -
KZO14_RS23185 (KZO14_23170) 33478..34911 + 1434 WP_001288435.1 DNA cytosine methyltransferase -
KZO14_RS23190 (KZO14_23175) 34945..36159 - 1215 WP_001532073.1 type II site-specific deoxyribonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS1 - 1..39170 39170


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-86)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T210616 WP_000220560.1 NZ_CP080068:31720-32001 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T210616 NZ_CP104579:c3376243-3375674 [Pseudomonas oleovorans]
ATGTTCAAGCCGCAGCTGGTGACTTTGCAACGTGGCGCTCTGCGCCTGGAACCGCTCTCTGACGCCGATATCCCCGCGCT
GGTGGCGCTGGCCGAAGCCAATCGCGAGGAGCTGCTGTACATGAGCGGTACTCAGCGACTGGACTGGTACCGCAGCGCCC
TGGCCGATATGCGCGAGCAGCGGGCACTGCCGTTCGTCATTCGTCTGGGTAACGAGTGGGTAGGCACCACCCGCTTCGCC
GACTTCATGAACCCCCTGCCGGCCTGTGAAATCGGCTGGACCTGGCTCGACCGCAATCAGCATGGCAGCGGGTTGAACAC
CAGCATCAAGTACCTGATGCTCAAGCACGCTTTCGAAAATTGGGGCATGGTTCGCGTGCAACTGAAAACTGCCGCCAGCA
ACCTGCGTTCGCAACGCGCCATCGAGAAGCTTGGTGCCGTTCGTGAAGGGTTGCTGCGCAACCATCGCCGTCTGGCTGAT
GGCCGACTCGATGACACCGTGCTGTACAGCATCACCGACCTGGAATGGCCGGCGCTGCGTGGGGCCATGGAGGCGGGCTT
CAACGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT210616 WP_000121743.1 NZ_CP080068:31479-31730 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT210616 NZ_CP104579:c3375668-3374841 [Pseudomonas oleovorans]
ATGCACAGTCGCGAGCAGACCCGCTTCTGGCAAGCTTCCGCATTGAGCGGCGTCGAGCTGTTGCAGGCGCGCTACCTTGA
ACAGCGCTTCGCGCCCCACGTGCATGAAGGTTTCGTGTTCACCGTGATCGAGCATGGCGCCCAGCGCTTTCGTCATCGCG
GTTGTGATCATCTGGCCCCACAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGCTCCAAGGCGCACGAA
GACGGTTGGCGCTATCGCGGTTTCTATCCCGACAACGCCCAGGTTCTGGGGGCGCTGCAGGAGCTGGGTCTGGCCAAGGC
TGGCATGCCGTCGTTTGCCTTCAGTGTGCTGCATGATCCACGTTTGCACGCGGCCTTTCTGCAACTGCACCAACTGCTCG
AGGGCGGCGCCGAGGCACTGCAGCAGCAACTGGCCTGGCGTGAGGCAATGCTGCTGCTGTTTCAGCACCATGCGCAGCTT
GCCGAACCACCTGCGCCTGGGCGTGAGCCCTGGGCAGTGGCTTGTGCCAAGCAGATGCTCGCCGAGCGGCTGATCGAGCC
GCCCTCGCTGGAGGAACTGGCGGCTGCGGTCAATCTTTCACCGTTTCATTTCGCTCGAGTGTTCCGCCGCGAGACCGGCT
TGCCACCGCATGCCTGGCTCAAGCAACGGCGCCTGGAGCAGGCGCGGGCGTTGCTCAAGACGGGCTGCACGGCGGTCGCT
GTGGCCATGCAGTTGGGCTTCGCTGATCAGAGCCACTTGTCGCGACAGTTCAAGCAGGTTTATGGCGTGAGCCCTGGCGA
ATATCGCAGCGCAGTGGCACGAAGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G3CAN5


Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References