Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4153367..4153962 Replicon chromosome
Accession NZ_CP080066
Organism Escherichia coli strain 19SZHZ803Rt

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KZO14_RS19850 Protein ID WP_000239579.1
Coordinates 4153367..4153717 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag KZO14_RS19855 Protein ID WP_001223207.1
Coordinates 4153711..4153962 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO14_RS19830 (4148643) 4148643..4149665 - 1023 WP_001296689.1 ABC transporter permease -
KZO14_RS19835 (4149679) 4149679..4151181 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
KZO14_RS19840 (4151491) 4151491..4152447 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KZO14_RS19845 (4152757) 4152757..4153287 + 531 WP_000055072.1 inorganic diphosphatase -
KZO14_RS19850 (4153367) 4153367..4153717 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KZO14_RS19855 (4153711) 4153711..4153962 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KZO14_RS19860 (4154175) 4154175..4154516 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KZO14_RS19865 (4154519) 4154519..4158298 - 3780 WP_063122102.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T210613 WP_000239579.1 NZ_CP080066:c4153717-4153367 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T210613 NZ_CP104579:c1005962-1005684 [Pseudomonas oleovorans]
ATGATCCTGAGTTTCAGATGCGCAGAAACCCAGGCTCTGTTTGAGTCAGGAAGCTCCAGACGCTGGGCCAGCATTCTCAA
CGTGGCCACGCGGAAGCTGACGATGCTGAATGCAGCCGTTGAGCTGCGCGACCTTCGCTCCCCACCGGGCAACCGGCTGG
AGCAGCTACAGGGCAATCGAGCAGATCAACACAGCATCCGAATCAACGATCAATGGCGAATCTGCTTTGTGTGGACTGCC
GCTGGCCCTACACAAGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT210613 WP_001223207.1 NZ_CP080066:c4153962-4153711 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT210613 NZ_CP104579:c1005671-1005366 [Pseudomonas oleovorans]
ATGACTATCAACGGCATGCGCCCCGTTCACCCTGGCGAAGTGCTACGCGAAGAGTTCCTTGAACCGCTAGGCATGACCCC
AGCCGCACTGGCTCGCGCTCTGCATGTGTCGGCGCCGACCATCAATGACATCGTGCGGGAGCGTCGTGGCATTACCGCCG
ATACGGCTATTCGGCTAGGCCGCTACTTCGACACCTCAGCTCAGTTCTGGATGAACTTGCAGACCGAGTATGCCCTGGCG
ACCACTTACGCCGAGTCTGGCGCAGCCATCGAGCAGGCCATTGAGCCGCTACAGATAGCGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References