Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3619945..3620779 Replicon chromosome
Accession NZ_CP080066
Organism Escherichia coli strain 19SZHZ803Rt

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag KZO14_RS17375 Protein ID WP_039025883.1
Coordinates 3619945..3620322 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag KZO14_RS17380 Protein ID WP_039025882.1
Coordinates 3620411..3620779 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO14_RS17345 (3615203) 3615203..3616159 + 957 WP_000121330.1 molybdenum cofactor insertion chaperone PaoD -
KZO14_RS17350 (3616210) 3616210..3616548 + 339 Protein_3403 LysR substrate-binding domain-containing protein -
KZO14_RS17355 (3616886) 3616886..3618205 + 1320 WP_000144688.1 site-specific integrase -
KZO14_RS17360 (3618298) 3618298..3619146 - 849 WP_039025884.1 DUF4942 domain-containing protein -
KZO14_RS17365 (3619243) 3619243..3619440 - 198 WP_000772024.1 DUF957 domain-containing protein -
KZO14_RS17370 (3619460) 3619460..3619948 - 489 Protein_3407 DUF5983 family protein -
KZO14_RS17375 (3619945) 3619945..3620322 - 378 WP_039025883.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KZO14_RS17380 (3620411) 3620411..3620779 - 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZO14_RS17385 (3620829) 3620829..3621473 - 645 WP_039025881.1 hypothetical protein -
KZO14_RS17390 (3621488) 3621488..3621709 - 222 WP_000692312.1 DUF987 domain-containing protein -
KZO14_RS17395 (3621778) 3621778..3622254 - 477 WP_001186742.1 RadC family protein -
KZO14_RS17400 (3622269) 3622269..3622754 - 486 WP_063122055.1 antirestriction protein -
KZO14_RS17405 (3622845) 3622845..3623663 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3591473..3631094 39621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T210610 WP_039025883.1 NZ_CP080066:c3620322-3619945 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T210610 NZ_CP104562:3999343-4000206 [Roseateles sp. BIM B-1768]
ATGAATCTCGCCAATCCAAATGTCGCCGCGTCCATCCGTGCGCGCCTGCTCAACATTGCCAAAGCTCAGGGCGTCGATTT
CAATCAGGTGCTGGTGAGATTCGCGCTGGAGCGGATGCTCTACCGCATGACCCAATCGCAGCACGCGAACCGCTTTCTGC
TCAAGGGCGCACTGCTGTTCACGCTCTGGTACGACATGCCGCACCGGGCCACGCGCGACGCCGATCTGCTCGGCTTCGGC
GCGAGCGATTTGCCATCGATGGCCGACACCTTCCGCGACATCGCCGCCGTCGCTGGGCACGACGGCATCGCATTTGACCC
AGCCTCTGTCACCGTCGAGGAGATCCGCAAGGAGGCCGGCTACGGGGGCGTCCGCGTCAGCATCGCTGGCGAACTGGCCA
AGGCTCGCTGCAAGACGCAGATCGATGTCGGCTTCGGCGATGCCGTCACACCTGGGCCGGTGGAGTCGGTCTATCCGGTC
CTGCTGGACGATCTTCCCGCGCCACGGCTGCGGGCCTATCCGACGTACACGGTCATCGCGGAGAAACTCCACGCCATCGC
CCTGCTGGGCATGACCAACAGCCGCCTGAAAGACTACTTCGATCTGTCGGTGCTGTTGGAACGAGAAACGCTGGACGCCG
ATCTGCTGACCCAAGCGATCAAAGCCACTTTCGAGCGGCGCGGCATGTCCGTGCCCGATGCGGTTCCGATGGGGCTGACG
GACGACTTTGCAAACGATGCCTCGCGGCAGTCGCTGTGGTTGGCGTTCATCAAGAAGAACGAGCTTGCCGCAGAGCCGCT
GCCTGGGGTGGTGGACCGTTTGCGATCGGCTCTCGCACCCGCCTTGAACCGAGCCGCGAGTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT210610 WP_039025882.1 NZ_CP080066:c3620779-3620411 [Escherichia coli]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT210610 NZ_CP104562:3998741-3999346 [Roseateles sp. BIM B-1768]
ATGCTCCCGGACACCCATACCCAGCGCGTCCTCGGCCTGGCCGGCCAGAAGGGTCTGCTGCGCGCCAGCGATCTGGACGC
CATCGGTGCACCACGGATTGTTTTGACCCGCCTGACCGCCGCCGGGCTGCTGGAACGGGTGGGGCGCGGCCTGTATCGCC
TGCCCGCCTTCCAGGGATCCGAGCACGAGAGTCTTGCGACCGTTGCCACCAAGGCGCCGCAAGCCGTGTTCTGCCTGCTC
ACCGCGTTGCAGTTTCACGAGATGACCACGCAACTGCCGCGCCAGATCTGGATTGCGATGCCGCGCGGCAGCCATGTCCC
CCGGCTCGACTATCCGCCCATCAAGATGGTGCAGTTCACGGGCGACGCCTACACGGCGGGCGCCGAGGAGGTGGAGGGCG
ATGGCGTCAAGTTCAGGGTCTACGGGGTGGCCAAGACCGTGGCGGACTGTTTCAAGCACCGCCACAAGATCGGCCTGGAC
GTCGCGCTGGAAGCCCTGAAGGAGGCCCGGAGCCGCAACAAGGCCTCGGTCGATGACATCTGGCGCTTCGCCCAGGTCTG
CCGCGTGGCCAACGTGATGCGGCCCTACTTGGAGAGCCTTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References