Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 74859..75421 Replicon plasmid pPBPR1
Accession NC_005871
Organism Photobacterium profundum SS9

Toxin (Protein)


Gene name parE Uniprot ID Q6LW71
Locus tag PBPR_RS28995 Protein ID WP_011176797.1
Coordinates 75119..75421 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q6LW72
Locus tag PBPR_RS28990 Protein ID WP_011176796.1
Coordinates 74859..75119 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBPR_RS28970 70380..71414 - 1035 WP_011176792.1 hypothetical protein -
PBPR_RS28975 71507..72244 - 738 WP_011176793.1 IS6-like element ISPpr9 family transposase -
PBPR_RS28980 72382..72777 + 396 WP_041396078.1 hypothetical protein -
PBPR_RS28985 73628..74278 + 651 WP_011176795.1 hypothetical protein -
PBPR_RS28990 74859..75119 + 261 WP_011176796.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PBPR_RS28995 75119..75421 + 303 WP_011176797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PBPR_RS29000 75589..76602 + 1014 WP_011176798.1 DNA-binding protein -
PBPR_RS29005 76913..77149 - 237 WP_041396080.1 DinI family protein -
PBPR_RS29010 77981..78841 - 861 WP_049789070.1 hypothetical protein -
PBPR_RS29015 79373..79657 + 285 WP_011176801.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80033 80033
- flank IS/Tn - - 71507..72244 737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-63)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11488.38 Da        Isoelectric Point: 9.2785

>T21060 WP_011176797.1 NC_005871:75119-75421 [Photobacterium profundum SS9]
MSKYVLSTGAQTDLIDIRQYTLDKWGQVQWKGYFAELKSTMILLAENPAIGAKTLDLGDNYFRFPLKHHVIYYIQQPTQI
VIVAVLGKSMSPQKHFEIIN

Download         Length: 303 bp

>T21060 NC_005871:75119-75421 [Photobacterium profundum SS9]
ATGAGCAAATATGTACTGTCAACTGGCGCCCAAACAGATCTCATTGATATTCGACAATACACGCTAGATAAATGGGGACA
AGTTCAGTGGAAAGGCTACTTTGCAGAGCTTAAGTCGACGATGATCCTGCTGGCTGAAAACCCAGCGATTGGGGCCAAAA
CCTTAGATCTAGGCGATAACTATTTTCGTTTCCCTCTTAAACATCATGTCATCTACTACATTCAGCAACCGACACAAATT
GTCATTGTTGCCGTGCTAGGTAAGTCGATGTCCCCTCAAAAGCATTTCGAAATCATTAACTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9688.17 Da        Isoelectric Point: 4.4012

>AT21060 WP_011176796.1 NC_005871:74859-75119 [Photobacterium profundum SS9]
MQSLTANTAKTKFGDLLMKVQREPVQICKNGSPVAVVMSCEEYAQLEALKLQFIKMRFAAAEKDIAENNLVDGETFFNQL
EQDMLD

Download         Length: 261 bp

>AT21060 NC_005871:74859-75119 [Photobacterium profundum SS9]
ATGCAATCTTTAACGGCCAATACTGCCAAAACTAAATTTGGTGATCTACTCATGAAAGTGCAACGTGAGCCAGTACAGAT
CTGTAAGAACGGTTCACCTGTCGCTGTCGTCATGTCATGTGAAGAATATGCTCAACTAGAAGCCTTAAAACTGCAATTTA
TAAAAATGCGCTTTGCTGCCGCAGAAAAAGACATTGCTGAAAATAACCTTGTCGATGGCGAAACGTTTTTTAACCAACTA
GAACAGGACATGTTGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3J6B5

Antitoxin

Source ID Structure
AlphaFold DB Q6LW72

References