Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1337471..1338096 Replicon chromosome
Accession NZ_CP080066
Organism Escherichia coli strain 19SZHZ803Rt

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag KZO14_RS06515 Protein ID WP_000911329.1
Coordinates 1337698..1338096 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KZO14_RS06510 Protein ID WP_000450524.1
Coordinates 1337471..1337698 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO14_RS06485 (1333273) 1333273..1333743 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KZO14_RS06490 (1333743) 1333743..1334315 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KZO14_RS06495 (1334461) 1334461..1335339 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
KZO14_RS06500 (1335356) 1335356..1336390 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KZO14_RS06505 (1336603) 1336603..1337316 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KZO14_RS06510 (1337471) 1337471..1337698 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KZO14_RS06515 (1337698) 1337698..1338096 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
KZO14_RS06520 (1338243) 1338243..1339106 + 864 WP_001267498.1 neutral zinc metallopeptidase -
KZO14_RS06525 (1339121) 1339121..1341136 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
KZO14_RS06530 (1341210) 1341210..1341908 + 699 WP_000679823.1 esterase -
KZO14_RS06535 (1342018) 1342018..1342218 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T210597 WP_000911329.1 NZ_CP080066:1337698-1338096 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T210597 NZ_CP104557:873133-873360 [Pseudomonas promysalinigenes]
ATGCGCAGTCGTGAAGTGATCCAGCTCATTGAGGCGGACGGGTGGTACGAGGTCGAGGTCAAGGGCAGCCATCACCAGTT
CAGGCACCCGACGAAGAAGGGAAGGGTGACAGTACCTCATCCCAAGAGCGATCTTCCTACAAGCACCGTACACAGCATCC
TGAAGCAAGCTGGCTTGAAGCAGTCCAGTGGCTTCGATAGCTCGAACATCAGTGGAGACGCGCAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT210597 WP_000450524.1 NZ_CP080066:1337471-1337698 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT210597 NZ_CP104557:873357-873764 [Pseudomonas promysalinigenes]
ATGAAATTCCCAGTCGTATTGCACAAGGACGCTGATTCGGATTATGGCGTGACCGTTCCCGACGTGCCTGGTTGCTTCTC
TGCGGGCTCGACTGTCGCCCAAGCTCTGGAGAACGTTCAAGAGGCGCTAGCGCTGCATTTTGAGGGATTGGTTGCTGATA
ACGAAGCGCTTCCTCAAGCGCAGGAAGTCGACGTCCATGTGGCGAATTCCGATTATGCTGGTGGGGTCTGGGCTGTCGTT
GATTTCGATGTCACGCCTTACTTGGGGAAGGCCGTGCGGTTCAACGCAACATTGCCGGAAAACCTCCTTCAGCGGATCGA
TGAAAAAGTGAAGCGTGACCATCGGTATGCTTCTCGTTCTGGATTTCTCGCGTCGGCCGCTCTAAGAGAACTGGCGCTCG
CACACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References