Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 1039244..1039827 | Replicon | chromosome |
Accession | NZ_CP080066 | ||
Organism | Escherichia coli strain 19SZHZ803Rt |
Toxin (Protein)
Gene name | mazF | Uniprot ID | U9XFN8 |
Locus tag | KZO14_RS05070 | Protein ID | WP_000254745.1 |
Coordinates | 1039492..1039827 (+) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | KZO14_RS05065 | Protein ID | WP_000581937.1 |
Coordinates | 1039244..1039492 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZO14_RS05055 (1035583) | 1035583..1036884 | + | 1302 | WP_000046785.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
KZO14_RS05060 (1036932) | 1036932..1039166 | + | 2235 | WP_000226828.1 | GTP diphosphokinase | - |
KZO14_RS05065 (1039244) | 1039244..1039492 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
KZO14_RS05070 (1039492) | 1039492..1039827 | + | 336 | WP_000254745.1 | endoribonuclease MazF | Toxin |
KZO14_RS05075 (1039898) | 1039898..1040689 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
KZO14_RS05080 (1040917) | 1040917..1042554 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
KZO14_RS05085 (1042642) | 1042642..1043940 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
KZO14_RS05090 (1043996) | 1043996..1044358 | - | 363 | WP_000034929.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12158.08 Da Isoelectric Point: 8.4777
>T210596 WP_000254745.1 NZ_CP080066:1039492-1039827 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T210596 NZ_CP104557:336351-336575 [Pseudomonas promysalinigenes]
CTGGGGGATACGGTTCGGCAGCAACTCAAAAGAAAACTCGCCTCGGTTTTGCTTAATCCGAGGGTTGAGGCAAACCGGCT
GGATAGCTTGCCGAACGGCTACAAGATAAAGCTGCGCAGTAGCGGCTACCGATTGATTTACCAGGTGGTCGATCAGGAGG
AGACATCAGAAGTCCTCCGCGTTGCTGCGCGGCAGTTTTACGCGCTTGCTGGTATTGGCTTCTAA
CTGGGGGATACGGTTCGGCAGCAACTCAAAAGAAAACTCGCCTCGGTTTTGCTTAATCCGAGGGTTGAGGCAAACCGGCT
GGATAGCTTGCCGAACGGCTACAAGATAAAGCTGCGCAGTAGCGGCTACCGATTGATTTACCAGGTGGTCGATCAGGAGG
AGACATCAGAAGTCCTCCGCGTTGCTGCGCGGCAGTTTTACGCGCTTGCTGGTATTGGCTTCTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT210596 WP_000581937.1 NZ_CP080066:1039244-1039492 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT210596 NZ_CP104557:336071-336310 [Pseudomonas promysalinigenes]
ATGGCATCCATCAATGTTCGTATCGACGACGATCTCAAAATCCGAGCCTACCGTGAGCTCGAGCGGCTGGGTGTTACGCC
CTCCGAACTCATGCGCCAAGCCTTGCAGTACGTCGCTGAGCGCGGGCAATTGCCTTTCAAGCCTGTGCTCATGACGGATG
AAGATGAGGCGCTGCTGGCGACCGTTCGCGAGCGCCTTGCCGACCCTCAGCGAGTGAAGGTGTCGCTGGATGACCTATAG
ATGGCATCCATCAATGTTCGTATCGACGACGATCTCAAAATCCGAGCCTACCGTGAGCTCGAGCGGCTGGGTGTTACGCC
CTCCGAACTCATGCGCCAAGCCTTGCAGTACGTCGCTGAGCGCGGGCAATTGCCTTTCAAGCCTGTGCTCATGACGGATG
AAGATGAGGCGCTGCTGGCGACCGTTCGCGAGCGCCTTGCCGACCCTCAGCGAGTGAAGGTGTCGCTGGATGACCTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0XYM3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LMB4 |