Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 316009..316595 Replicon chromosome
Accession NZ_CP080066
Organism Escherichia coli strain 19SZHZ803Rt

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag KZO14_RS01490 Protein ID WP_042014162.1
Coordinates 316009..316239 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KZO14_RS01495 Protein ID WP_000593555.1
Coordinates 316236..316595 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO14_RS01480 (312046) 312046..314781 + 2736 WP_000149168.1 ribosome-associated ATPase/putative transporter RbbA -
KZO14_RS01485 (314781) 314781..315905 + 1125 WP_001314210.1 ABC transporter permease -
KZO14_RS01490 (316009) 316009..316239 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
KZO14_RS01495 (316236) 316236..316595 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KZO14_RS01500 (316715) 316715..317116 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
KZO14_RS01505 (317122) 317122..317928 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
KZO14_RS01510 (317925) 317925..318689 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
KZO14_RS01515 (318689) 318689..319522 - 834 WP_001008968.1 nickel ABC transporter permease subunit NikC -
KZO14_RS01520 (319519) 319519..320463 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T210592 WP_042014162.1 NZ_CP080066:316009-316239 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T210592 NZ_CP104555:c850421-850134 [Vibrio sp. J502]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAGTGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCGCCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAGGTATTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT210592 WP_000593555.1 NZ_CP080066:316236-316595 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT210592 NZ_CP104555:c850123-849806 [Vibrio sp. J502]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCAGCGGCATTAGGCAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References