Detailed information of TA system TA210588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1781..2328
• Replicon: plasmid p655Rt_IncBOKZ
• Accession: NZ_CP080057
• Organism: Escherichia coli strain 18SZHZ655Rt

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KZO13_RS23055
• Protein ID: WP_244461648.1
• Coordinates: 2050..2328 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: KZO13_RS23050
• Protein ID: WP_000079941.1
• Coordinates: 1781..2050 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZO13_RS23040 (KZO13_23025)	1..873	+	873	WP_000729440.1	incFII family plasmid replication initiator RepA	-
KZO13_RS23045 (KZO13_23030)	1568..1726	+	159	WP_032232331.1	hypothetical protein	-
KZO13_RS23050 (KZO13_23035)	1781..2050	+	270	WP_000079941.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
KZO13_RS23055 (KZO13_23040)	2050..2328	+	279	WP_244461648.1	type II toxin-antitoxin system toxin YacB	Toxin
KZO13_RS23060 (KZO13_23045)	2687..3874	-	1188	Protein_4	IS91 family transposase	-
KZO13_RS23065 (KZO13_23050)	3874..4239	-	366	WP_001611636.1	hypothetical protein	-
KZO13_RS23070 (KZO13_23055)	4329..4583	-	255	Protein_6	transposase zinc-binding domain-containing protein	-
KZO13_RS23075 (KZO13_23060)	4593..4781	-	189	WP_130055808.1	hypothetical protein	-
KZO13_RS23080 (KZO13_23065)	4916..5679	-	764	Protein_8	IS3-like element IS2 family transposase	-
KZO13_RS23085 (KZO13_23075)	5771..6061	+	291	Protein_9	integrase core domain-containing protein	-
KZO13_RS23090 (KZO13_23080)	6445..6633	+	189	WP_001051770.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..108275	108275

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10732.29 Da
• Isoelectric Point: 8.4615

>T210588 WP_244461648.1 NZ_CP080057:2050-2328 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLTAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T210588 NZ_CP104555:680533-681066 [Vibrio sp. J502]
GTGAGTTGGGGTAAAGAGTTTGTAGAACTTAGTAAGTCAAAGCATGACCGCGATTCATTTGACTGTGGAGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCGCATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCAAC
CACTGTTAAATCAAAAATTCGCTATTTGTGTATTTTATAGTGTTGCACCGAGTTCAATCAGTCGAGAAACATTGCCGGCA
CAACTAGCAAAGAAACTTCCTAGGTATCCAATCCCTGTTTTTCTTTTGGCTCAATTAGCTGTGCACAAAGAGTATCATGG
CTCTGGGCTCGGAAAAATTAGTCTAATTCGCGCACTGAAGTACTTATGGGAAGTGAATCATCACATGAGGGTATACGCAA
TAGTTGTGGACTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTTGGCTTTGAAGTATTGTGCGAATATAATGAG
CGTATTCGTATGTTCTTACCAATGAAAACGGTAGAACAGCTTTTTAATCAATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10252.58 Da
• Isoelectric Point: 7.2057

>AT210588 WP_000079941.1 NZ_CP080057:1781-2050 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT210588 NZ_CP104555:680114-680536 [Vibrio sp. J502]
GTGTATTTTTTGAGTTCGGCGGTGCGTTGGCAACCCCTTAGCCGGGCGTTATACTCTCTCTCGTTCCGTAAATTTTCTGT
ACTAATTGAATATGCCTTAAGTTTGCACTATAATCAATCAGCTTACGGAACATATCCGTACATTGGAGGGGTTATGGCAA
CGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAAGCATCGGCTTTACTTGGTTTAAAAAGT
CTCACTGAATATGTAGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGTATGAAAGTATTATGGTTAAAGA
CAGTGTTTTTGACGAATTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTA
CAGAGAAGAGTGGTATCAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A629TXC5