Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 5506299..5506821 Replicon chromosome
Accession NZ_CP080029
Organism Streptomyces anulatus strain VUW1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KZO11_RS24425 Protein ID WP_219611973.1
Coordinates 5506299..5506562 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KZO11_RS24430 Protein ID WP_219611974.1
Coordinates 5506555..5506821 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO11_RS24405 (KZO11_24390) 5502138..5503127 + 990 WP_176739499.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
KZO11_RS24410 (KZO11_24395) 5503166..5503915 + 750 WP_219611972.1 ROK family protein -
KZO11_RS24415 (KZO11_24400) 5504099..5504677 - 579 WP_219614295.1 hypothetical protein -
KZO11_RS24420 (KZO11_24405) 5505080..5506168 + 1089 WP_097963920.1 redox-regulated ATPase YchF -
KZO11_RS24425 (KZO11_24410) 5506299..5506562 - 264 WP_219611973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZO11_RS24430 (KZO11_24415) 5506555..5506821 - 267 WP_219611974.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZO11_RS24435 (KZO11_24420) 5507504..5507803 + 300 WP_219611975.1 hypothetical protein -
KZO11_RS24440 (KZO11_24425) 5508858..5509463 + 606 WP_219611976.1 response regulator transcription factor -
KZO11_RS24445 (KZO11_24430) 5509486..5510517 - 1032 WP_257895261.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 88 a.a.        Molecular weight: 9999.42 Da        Isoelectric Point: 9.5559

>T210565 WP_219611973.1 NZ_CP080029:c5506562-5506299 [Streptomyces anulatus]
VSEYRAVFHPEARAELRKVPRDAALRILTKLAELEADPFGFSTTALVSQPERRRLRVGDYRVIYTVDNGELIVWVIRVGH
RSTVYDS

Download         Length: 264 bp

>T210565 NZ_CP104541:2255-2533 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10206.62 Da        Isoelectric Point: 4.7777

>AT210565 WP_219611974.1 NZ_CP080029:c5506821-5506555 [Streptomyces anulatus]
MTQMPIESIRDVRAHLAEVVERADRDDTPTIITRRGKEVAAVVSIEVLRKYQEWEEREINRLIDERMASRSAGIPIEDVM
KETLARSE

Download         Length: 267 bp

>AT210565 NZ_CP104541:1986-2255 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References