Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE-Phd |
Location | 5506299..5506821 | Replicon | chromosome |
Accession | NZ_CP080029 | ||
Organism | Streptomyces anulatus strain VUW1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | KZO11_RS24425 | Protein ID | WP_219611973.1 |
Coordinates | 5506299..5506562 (-) | Length | 88 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | KZO11_RS24430 | Protein ID | WP_219611974.1 |
Coordinates | 5506555..5506821 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZO11_RS24405 (KZO11_24390) | 5502138..5503127 | + | 990 | WP_176739499.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
KZO11_RS24410 (KZO11_24395) | 5503166..5503915 | + | 750 | WP_219611972.1 | ROK family protein | - |
KZO11_RS24415 (KZO11_24400) | 5504099..5504677 | - | 579 | WP_219614295.1 | hypothetical protein | - |
KZO11_RS24420 (KZO11_24405) | 5505080..5506168 | + | 1089 | WP_097963920.1 | redox-regulated ATPase YchF | - |
KZO11_RS24425 (KZO11_24410) | 5506299..5506562 | - | 264 | WP_219611973.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KZO11_RS24430 (KZO11_24415) | 5506555..5506821 | - | 267 | WP_219611974.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KZO11_RS24435 (KZO11_24420) | 5507504..5507803 | + | 300 | WP_219611975.1 | hypothetical protein | - |
KZO11_RS24440 (KZO11_24425) | 5508858..5509463 | + | 606 | WP_219611976.1 | response regulator transcription factor | - |
KZO11_RS24445 (KZO11_24430) | 5509486..5510517 | - | 1032 | WP_257895261.1 | Gfo/Idh/MocA family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 9999.42 Da Isoelectric Point: 9.5559
>T210565 WP_219611973.1 NZ_CP080029:c5506562-5506299 [Streptomyces anulatus]
VSEYRAVFHPEARAELRKVPRDAALRILTKLAELEADPFGFSTTALVSQPERRRLRVGDYRVIYTVDNGELIVWVIRVGH
RSTVYDS
VSEYRAVFHPEARAELRKVPRDAALRILTKLAELEADPFGFSTTALVSQPERRRLRVGDYRVIYTVDNGELIVWVIRVGH
RSTVYDS
Download Length: 264 bp
>T210565 NZ_CP104541:2255-2533 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10206.62 Da Isoelectric Point: 4.7777
>AT210565 WP_219611974.1 NZ_CP080029:c5506821-5506555 [Streptomyces anulatus]
MTQMPIESIRDVRAHLAEVVERADRDDTPTIITRRGKEVAAVVSIEVLRKYQEWEEREINRLIDERMASRSAGIPIEDVM
KETLARSE
MTQMPIESIRDVRAHLAEVVERADRDDTPTIITRRGKEVAAVVSIEVLRKYQEWEEREINRLIDERMASRSAGIPIEDVM
KETLARSE
Download Length: 267 bp
>AT210565 NZ_CP104541:1986-2255 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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