Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1855920..1856411 Replicon chromosome
Accession NZ_CP080013
Organism Macrococcus caseolyticus strain 19Msa1047

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KYI12_RS09895 Protein ID WP_101141631.1
Coordinates 1855920..1856270 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KYI12_RS09900 Protein ID WP_099482357.1
Coordinates 1856271..1856411 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI12_RS09870 (KYI12_09865) 1851028..1853163 - 2136 WP_219493138.1 Tex family protein -
KYI12_RS09875 (KYI12_09870) 1853240..1854007 - 768 WP_219493140.1 RNA polymerase sigma factor SigB -
KYI12_RS09880 (KYI12_09875) 1854012..1854455 - 444 WP_101141625.1 anti-sigma B factor RsbW -
KYI12_RS09885 (KYI12_09880) 1854460..1854783 - 324 WP_101141627.1 anti-sigma factor antagonist -
KYI12_RS09890 (KYI12_09885) 1854864..1855871 - 1008 WP_219493142.1 PP2C family protein-serine/threonine phosphatase -
KYI12_RS09895 (KYI12_09890) 1855920..1856270 - 351 WP_101141631.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KYI12_RS09900 (KYI12_09895) 1856271..1856411 - 141 WP_099482357.1 antitoxin MazE Antitoxin
KYI12_RS09905 (KYI12_09900) 1856472..1857614 - 1143 WP_219493143.1 alanine racemase -
KYI12_RS09910 (KYI12_09905) 1857640..1857996 - 357 WP_101141634.1 holo-ACP synthase -
KYI12_RS09915 (KYI12_09910) 1857938..1858459 - 522 WP_219493144.1 PH domain-containing protein -
KYI12_RS09920 (KYI12_09915) 1858443..1859954 - 1512 WP_219493145.1 PH domain-containing protein -
KYI12_RS09925 (KYI12_09920) 1859944..1860420 - 477 WP_219493146.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12726.89 Da        Isoelectric Point: 10.1643

>T210561 WP_101141631.1 NZ_CP080013:c1856270-1855920 [Macrococcus caseolyticus]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTTHRLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T210561 NZ_CP104540:83863-84279 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5352.91 Da        Isoelectric Point: 3.6323

>AT210561 WP_099482357.1 NZ_CP080013:c1856411-1856271 [Macrococcus caseolyticus]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNYQTYTFDGE

Download         Length: 141 bp

>AT210561 NZ_CP104540:83636-83866 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References