Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 779893..780977 | Replicon | chromosome |
| Accession | NC_005835 | ||
| Organism | Thermus thermophilus HB27 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | TT_RS04045 | Protein ID | WP_011173231.1 |
| Coordinates | 780366..780977 (-) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | Q72JH4 |
| Locus tag | TT_RS04040 | Protein ID | WP_011173230.1 |
| Coordinates | 779893..780306 (-) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TT_RS04015 | 774943..775887 | + | 945 | WP_041443443.1 | TAXI family TRAP transporter solute-binding subunit | - |
| TT_RS04020 | 775950..777923 | + | 1974 | WP_011173226.1 | TRAP transporter permease | - |
| TT_RS04025 | 777939..778664 | + | 726 | WP_172619226.1 | ATP-binding cassette domain-containing protein | - |
| TT_RS04030 | 778671..779087 | + | 417 | WP_011173228.1 | hypothetical protein | - |
| TT_RS04035 | 779062..779889 | - | 828 | WP_011173229.1 | patatin-like phospholipase family protein | - |
| TT_RS04040 | 779893..780306 | - | 414 | WP_011173230.1 | helix-turn-helix domain-containing protein | Antitoxin |
| TT_RS04045 | 780366..780977 | - | 612 | WP_011173231.1 | PIN domain-containing protein | Toxin |
| TT_RS04050 | 781004..781768 | + | 765 | WP_011173232.1 | indole-3-glycerol phosphate synthase TrpC | - |
| TT_RS04055 | 781773..782480 | + | 708 | WP_011173233.1 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase | - |
| TT_RS04060 | 782468..782785 | + | 318 | WP_011173234.1 | DUF1049 domain-containing protein | - |
| TT_RS04065 | 782782..784782 | + | 2001 | WP_011173235.1 | single-stranded-DNA-specific exonuclease RecJ | - |
| TT_RS04070 | 784754..785317 | + | 564 | WP_011173236.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 23534.41 Da Isoelectric Point: 6.1323
>T21056 WP_011173231.1 NC_005835:c780977-780366 [Thermus thermophilus HB27]
MARPLPQTLFLDACVLYPAPIRDLFMGLALEGLVRLKWNRRVQEEWIHNLLQDRPDLTPEQQARIRATPEKMKEVLAFQE
PLVEGYESLVEKIQLPDANDRHVVAAAWWGKAEAILTFNLKDFPEEELGRWELLALHPDDYLTELAERLIRKNFLPDPLL
RVLKRQRCALRKPPLGVEDFLEILRRAGLATFTEALGPYKGHL
MARPLPQTLFLDACVLYPAPIRDLFMGLALEGLVRLKWNRRVQEEWIHNLLQDRPDLTPEQQARIRATPEKMKEVLAFQE
PLVEGYESLVEKIQLPDANDRHVVAAAWWGKAEAILTFNLKDFPEEELGRWELLALHPDDYLTELAERLIRKNFLPDPLL
RVLKRQRCALRKPPLGVEDFLEILRRAGLATFTEALGPYKGHL
Download Length: 612 bp
>T21056 NC_005835:c780977-780366 [Thermus thermophilus HB27]
ATGGCCCGCCCTCTTCCCCAAACCCTCTTTTTGGACGCCTGCGTCCTCTACCCCGCTCCCATCCGGGACCTTTTCATGGG
CCTGGCCTTGGAGGGACTTGTGCGGCTCAAGTGGAACCGGCGCGTCCAGGAGGAGTGGATCCACAACCTGCTTCAGGACC
GCCCTGACCTCACCCCGGAGCAGCAGGCGCGGATCAGGGCCACCCCTGAAAAGATGAAGGAGGTTTTGGCGTTCCAAGAA
CCCCTAGTAGAGGGCTACGAAAGCCTGGTGGAGAAAATCCAGCTCCCCGATGCAAACGACCGCCATGTGGTGGCCGCCGC
CTGGTGGGGAAAAGCAGAGGCCATCCTTACCTTCAACCTCAAGGATTTCCCCGAAGAGGAGCTTGGCCGCTGGGAACTCC
TGGCCCTCCACCCCGACGACTACCTTACGGAGCTCGCCGAAAGGCTGATCCGGAAAAACTTCCTGCCCGACCCCCTTCTC
AGGGTCCTTAAGCGCCAGCGGTGCGCCTTGCGCAAACCCCCGCTCGGGGTGGAGGACTTCTTGGAAATCCTGCGACGGGC
CGGGTTGGCCACCTTTACCGAGGCGCTTGGCCCCTACAAGGGGCACCTCTAA
ATGGCCCGCCCTCTTCCCCAAACCCTCTTTTTGGACGCCTGCGTCCTCTACCCCGCTCCCATCCGGGACCTTTTCATGGG
CCTGGCCTTGGAGGGACTTGTGCGGCTCAAGTGGAACCGGCGCGTCCAGGAGGAGTGGATCCACAACCTGCTTCAGGACC
GCCCTGACCTCACCCCGGAGCAGCAGGCGCGGATCAGGGCCACCCCTGAAAAGATGAAGGAGGTTTTGGCGTTCCAAGAA
CCCCTAGTAGAGGGCTACGAAAGCCTGGTGGAGAAAATCCAGCTCCCCGATGCAAACGACCGCCATGTGGTGGCCGCCGC
CTGGTGGGGAAAAGCAGAGGCCATCCTTACCTTCAACCTCAAGGATTTCCCCGAAGAGGAGCTTGGCCGCTGGGAACTCC
TGGCCCTCCACCCCGACGACTACCTTACGGAGCTCGCCGAAAGGCTGATCCGGAAAAACTTCCTGCCCGACCCCCTTCTC
AGGGTCCTTAAGCGCCAGCGGTGCGCCTTGCGCAAACCCCCGCTCGGGGTGGAGGACTTCTTGGAAATCCTGCGACGGGC
CGGGTTGGCCACCTTTACCGAGGCGCTTGGCCCCTACAAGGGGCACCTCTAA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15107.62 Da Isoelectric Point: 8.5332
>AT21056 WP_011173230.1 NC_005835:c780306-779893 [Thermus thermophilus HB27]
MGGLLFTSTSSVEAVKAFREKLAPGKVLRLEEASLVLTPELARLFQELLGALLRGEAVRIVPLEAELTTGQAAELLGVSR
PYLVRLLEEGKIPHHKVGTHRRVRARDLLAYLEASRKRGRELLDELIGEAQELGLGY
MGGLLFTSTSSVEAVKAFREKLAPGKVLRLEEASLVLTPELARLFQELLGALLRGEAVRIVPLEAELTTGQAAELLGVSR
PYLVRLLEEGKIPHHKVGTHRRVRARDLLAYLEASRKRGRELLDELIGEAQELGLGY
Download Length: 414 bp
>AT21056 NC_005835:c780306-779893 [Thermus thermophilus HB27]
ATGGGCGGTCTCCTCTTCACCTCTACGTCCTCGGTGGAGGCGGTTAAGGCCTTCCGGGAAAAGCTTGCCCCCGGGAAGGT
TCTGCGCCTCGAGGAAGCCTCTTTGGTGCTCACCCCGGAGCTGGCCCGGCTTTTCCAGGAGCTTTTGGGGGCGCTTTTGC
GGGGTGAGGCGGTGCGCATCGTTCCCTTGGAAGCCGAGCTCACCACGGGCCAGGCGGCCGAGCTCCTCGGGGTCTCCCGG
CCTTACCTGGTCCGGCTTTTGGAGGAAGGCAAGATTCCCCACCACAAGGTGGGGACCCACCGCCGGGTCCGGGCCAGGGA
CCTTCTGGCCTACCTGGAGGCCTCCCGGAAGCGGGGCAGGGAGCTTTTGGACGAGCTCATCGGCGAGGCCCAAGAGCTCG
GCCTGGGGTATTAG
ATGGGCGGTCTCCTCTTCACCTCTACGTCCTCGGTGGAGGCGGTTAAGGCCTTCCGGGAAAAGCTTGCCCCCGGGAAGGT
TCTGCGCCTCGAGGAAGCCTCTTTGGTGCTCACCCCGGAGCTGGCCCGGCTTTTCCAGGAGCTTTTGGGGGCGCTTTTGC
GGGGTGAGGCGGTGCGCATCGTTCCCTTGGAAGCCGAGCTCACCACGGGCCAGGCGGCCGAGCTCCTCGGGGTCTCCCGG
CCTTACCTGGTCCGGCTTTTGGAGGAAGGCAAGATTCCCCACCACAAGGTGGGGACCCACCGCCGGGTCCGGGCCAGGGA
CCTTCTGGCCTACCTGGAGGCCTCCCGGAAGCGGGGCAGGGAGCTTTTGGACGAGCTCATCGGCGAGGCCCAAGAGCTCG
GCCTGGGGTATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|