Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 6697257..6698477 Replicon chromosome
Accession NZ_CP080011
Organism Pseudomonas aeruginosa strain TL3773

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZH79_RS31170 Protein ID WP_003160088.1
Coordinates 6697257..6697835 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZH79_RS31175 Protein ID WP_003088112.1
Coordinates 6697923..6698477 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH79_RS31155 (KZH79_31150) 6692533..6693810 + 1278 WP_003102743.1 TolC family protein -
KZH79_RS31160 (KZH79_31155) 6693800..6695971 + 2172 WP_009876279.1 type I secretion system permease/ATPase -
KZH79_RS31165 (KZH79_31160) 6695961..6697148 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KZH79_RS31170 (KZH79_31165) 6697257..6697835 - 579 WP_003160088.1 HD domain-containing protein Toxin
KZH79_RS31175 (KZH79_31170) 6697923..6698477 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KZH79_RS31180 (KZH79_31175) 6698635..6700830 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KZH79_RS31185 (KZH79_31180) 6700835..6701296 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
KZH79_RS31190 (KZH79_31185) 6701627..6701950 + 324 WP_003102734.1 multidrug efflux SMR transporter -
KZH79_RS31195 (KZH79_31190) 6701963..6702361 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KZH79_RS31200 (KZH79_31195) 6702358..6702909 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T210558 WP_003160088.1 NZ_CP080011:c6697835-6697257 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T210558 NZ_CP104540:c41015-40737 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATAGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAACCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGTACAGAAGTGGCCATAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT210558 WP_003088112.1 NZ_CP080011:c6698477-6697923 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT210558 NZ_CP104540:c41284-41015 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References