Detailed information of TA system TA210557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 5693797..5695055
• Replicon: chromosome
• Accession: NZ_CP080011
• Organism: Pseudomonas aeruginosa strain TL3773

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: KZH79_RS26285
• Protein ID: WP_003112528.1
• Coordinates: 5694300..5695055 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KZH79_RS26280
• Protein ID: WP_003086329.1
• Coordinates: 5693797..5694165 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZH79_RS26260 (KZH79_26260)	5689960..5690235	+	276	WP_169057979.1	zinc ribbon domain-containing protein	-
KZH79_RS26265 (KZH79_26265)	5690238..5690714	-	477	WP_003112531.1	hypothetical protein	-
KZH79_RS26270 (KZH79_26270)	5690793..5692382	+	1590	WP_074231416.1	aldehyde dehydrogenase family protein	-
KZH79_RS26275 (KZH79_26275)	5692438..5693724	+	1287	WP_003163134.1	FAD-binding oxidoreductase	-
KZH79_RS26280 (KZH79_26280)	5693797..5694165	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KZH79_RS26285 (KZH79_26285)	5694300..5695055	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
KZH79_RS26290 (KZH79_26290)	5695823..5697184	+	1362	WP_073647918.1	DNA recombination protein RmuC	-
KZH79_RS26295 (KZH79_26295)	5697339..5699882	-	2544	WP_031755663.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T210557 WP_003112528.1 NZ_CP080011:5694300-5695055 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T210557 NZ_CP104539:c4391856-4391683 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT210557 WP_003086329.1 NZ_CP080011:5693797-5694165 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT210557 NZ_CP104539:c4392180-4391884 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7