210553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3920742..3921247 Replicon chromosome
Accession NZ_CP080011
Organism Pseudomonas aeruginosa strain TL3773

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag KZH79_RS17795 Protein ID WP_003121619.1
Coordinates 3920742..3921023 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag KZH79_RS17800 Protein ID WP_003112628.1
Coordinates 3921020..3921247 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH79_RS17770 (KZH79_17770) 3915993..3917342 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
KZH79_RS17775 (KZH79_17775) 3917391..3918077 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KZH79_RS17780 (KZH79_17780) 3918178..3918912 + 735 WP_003117208.1 GntR family transcriptional regulator -
KZH79_RS17785 (KZH79_17785) 3919092..3919502 + 411 WP_003101225.1 aegerolysin family protein -
KZH79_RS17790 (KZH79_17790) 3919534..3920442 - 909 WP_016561475.1 LysR family transcriptional regulator -
KZH79_RS17795 (KZH79_17795) 3920742..3921023 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
KZH79_RS17800 (KZH79_17800) 3921020..3921247 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
KZH79_RS17805 (KZH79_17805) 3921423..3922043 - 621 WP_003101226.1 hypothetical protein -
KZH79_RS17810 (KZH79_17810) 3922144..3922644 + 501 WP_003112629.1 LEA type 2 family protein -
KZH79_RS17815 (KZH79_17815) 3922717..3923058 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KZH79_RS17820 (KZH79_17820) 3923140..3924567 - 1428 WP_003083784.1 GABA permease -
KZH79_RS17825 (KZH79_17825) 3924736..3926229 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T210553 WP_003121619.1 NZ_CP080011:c3921023-3920742 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T210553 NZ_CP104539:3835755-3836033 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT210553 WP_003112628.1 NZ_CP080011:c3921247-3921020 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT210553 NZ_CP104539:3835492-3835752 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References