Detailed information of TA system TA021055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 110322..110974
• Replicon: chromosome
• Accession: NC_005835
• Organism: Thermus thermophilus HB27

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q72LD4
• Locus tag: TT_RS00645
• Protein ID: WP_011172580.1
• Coordinates: 110322..110714 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q72LD3
• Locus tag: TT_RS00650
• Protein ID: WP_011172581.1
• Coordinates: 110714..110974 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TT_RS00610	105564..105902	-	339	WP_008631771.1	hypothetical protein	-
TT_RS00615	105895..107337	-	1443	WP_041443314.1	2-phosphoglycerate kinase	-
TT_RS00630	107622..108011	+	390	WP_011172577.1	NADH-quinone oxidoreductase subunit 15	-
TT_RS00635	108014..109111	-	1098	WP_011172578.1	radical SAM family heme chaperone HemW	-
TT_RS00640	109117..110337	-	1221	WP_011172579.1	glycerate kinase	-
TT_RS00645	110322..110714	-	393	WP_011172580.1	type II toxin-antitoxin system VapC family toxin	Toxin
TT_RS00650	110714..110974	-	261	WP_011172581.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TT_RS00655	111007..112263	-	1257	WP_011172582.1	glycolate oxidase subunit GlcF	-
TT_RS00660	112268..113311	-	1044	WP_011172583.1	FAD-binding protein	-
TT_RS00665	113298..114680	-	1383	WP_011172584.1	FAD-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-85)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14693.82 Da
• Isoelectric Point: 6.1004

>T21055 WP_011172580.1 NC_005835:c110714-110322 [Thermus thermophilus HB27]
MVLDASALLAVLFREEGYEELLEELRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGRHPAGLNFGDCLSYALARVEGEPLLYKGQDFDRTDLAWKPS

Nucleotide

• Length: 393 bp

>T21055 NC_005835:c110714-110322 [Thermus thermophilus HB27]
ATGGTGCTGGACGCTTCCGCCCTTCTGGCCGTTCTCTTCCGGGAAGAGGGGTACGAGGAGCTTTTGGAGGAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGAACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTTACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAGGCACCCCGCCGGGCTCAACTTCGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGACTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10028.52 Da
• Isoelectric Point: 4.8272

>AT21055 WP_011172581.1 NC_005835:c110974-110714 [Thermus thermophilus HB27]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKQGFDRVIRFLEEEVWPQIPPELLGKGISKEEEEEILG
YGKEGY

Nucleotide

• Length: 261 bp

>AT21055 NC_005835:c110974-110714 [Thermus thermophilus HB27]
ATGGCCCTCACCATCCGCAACAAGGAGGTGGAGCGCCTGGCCGAAGAGGTGGCCCGCCTCGCCGGGGAGACCAAGACGGA
GGCGGTGAGGAAGGCCCTGGAGATGCGCCTTAGGGAGCTCCAGAGGAAGCAGGGCTTTGACCGGGTGATCCGCTTCCTGG
AAGAGGAAGTCTGGCCCCAAATCCCGCCGGAGCTTTTGGGGAAGGGGATCTCCAAGGAAGAGGAGGAAGAGATCCTGGGG
TACGGCAAGGAGGGGTACTGA

Structures

Toxin

• AlphaFold DB: Q72LD4

Antitoxin

• AlphaFold DB: Q72LD3