Detailed information of TA system TA210549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4452869..4454127
• Replicon: chromosome
• Accession: NZ_CP080007
• Organism: Pseudomonas aeruginosa strain S-1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KXE03_RS20375
• Protein ID: WP_023109087.1
• Coordinates: 4452869..4453624 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KXE03_RS20380
• Protein ID: WP_003086329.1
• Coordinates: 4453759..4454127 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXE03_RS20365 (KXE03_20355)	4448042..4450585	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
KXE03_RS20370 (KXE03_20360)	4450740..4452101	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
KXE03_RS20375 (KXE03_20365)	4452869..4453624	-	756	WP_023109087.1	RES family NAD+ phosphorylase	Toxin
KXE03_RS20380 (KXE03_20370)	4453759..4454127	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KXE03_RS20385 (KXE03_20375)	4454200..4455486	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
KXE03_RS20390 (KXE03_20380)	4455542..4457131	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
KXE03_RS20395 (KXE03_20385)	4457210..4457686	+	477	WP_003140638.1	hypothetical protein	-
KXE03_RS20400 (KXE03_20390)	4457689..4457964	-	276	WP_172826506.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28264.40 Da
• Isoelectric Point: 7.7294

>T210549 WP_023109087.1 NZ_CP080007:c4453624-4452869 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T210549 NZ_CP104539:2733505-2733612 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT210549 WP_003086329.1 NZ_CP080007:c4454127-4453759 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT210549 NZ_CP104539:c2733452-2733391 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: V6AJU7