Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144767..145272 Replicon chromosome
Accession NZ_CP080007
Organism Pseudomonas aeruginosa strain S-1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag KXE03_RS00665 Protein ID WP_003083773.1
Coordinates 144767..145048 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag KXE03_RS00670 Protein ID WP_003083775.1
Coordinates 145045..145272 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXE03_RS00640 (KXE03_00640) 140018..141367 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
KXE03_RS00645 (KXE03_00645) 141416..142102 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KXE03_RS00650 (KXE03_00650) 142203..142937 + 735 WP_003083764.1 GntR family transcriptional regulator -
KXE03_RS00655 (KXE03_00655) 143117..143527 + 411 WP_003110659.1 aegerolysin family protein -
KXE03_RS00660 (KXE03_00660) 143559..144467 - 909 WP_003083769.1 LysR family transcriptional regulator -
KXE03_RS00665 (KXE03_00665) 144767..145048 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
KXE03_RS00670 (KXE03_00670) 145045..145272 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
KXE03_RS00675 (KXE03_00675) 145448..146068 - 621 WP_003101226.1 hypothetical protein -
KXE03_RS00680 (KXE03_00680) 146169..146669 + 501 WP_003101228.1 LEA type 2 family protein -
KXE03_RS00685 (KXE03_00685) 146742..147083 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KXE03_RS00690 (KXE03_00690) 147165..148592 - 1428 WP_003083784.1 GABA permease -
KXE03_RS00695 (KXE03_00695) 148761..150254 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T210546 WP_003083773.1 NZ_CP080007:c145048-144767 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T210546 NZ_CP104539:2112976-2113079 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT210546 WP_003083775.1 NZ_CP080007:c145272-145045 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT210546 NZ_CP104539:c2113117-2112846 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References