Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1468396..1468951 Replicon chromosome
Accession NC_005823
Organism Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130

Toxin (Protein)


Gene name chpK Uniprot ID Q72T28
Locus tag LIC_RS06135 Protein ID WP_000617907.1
Coordinates 1468631..1468951 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag LIC_RS06130 Protein ID WP_000844758.1
Coordinates 1468396..1468644 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIC_RS06115 1464048..1466030 + 1983 WP_000802798.1 GAF domain-containing protein -
LIC_RS23130 1466672..1467130 - 459 WP_000453263.1 hypothetical protein -
LIC_RS06125 1467284..1467580 + 297 WP_000477061.1 helix-turn-helix domain-containing protein -
LIC_RS06130 1468396..1468644 + 249 WP_000844758.1 ribbon-helix-helix domain-containing protein Antitoxin
LIC_RS06135 1468631..1468951 + 321 WP_000617907.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LIC_RS06140 1469951..1470943 - 993 WP_000041092.1 aldolase -
LIC_RS06145 1471083..1472018 - 936 WP_000004530.1 ornithine carbamoyltransferase -
LIC_RS06155 1472822..1473289 + 468 WP_000060053.1 hypothetical protein -
LIC_RS06160 1473286..1473690 + 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11644.43 Da        Isoelectric Point: 9.8447

>T21053 WP_000617907.1 NC_005823:1468631-1468951 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGKVEIGL

Download         Length: 321 bp

>T21053 NC_005823:1468631-1468951 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTCTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTAAAGTTGAAATTGGGCTTTA
G

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT21053 WP_000844758.1 NC_005823:1468396-1468644 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT21053 NC_005823:1468396-1468644 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
ATGAAGACGGCGATTTCAATTCCTGATGAGTTATTTAGGGCTGCCGAGAAAATAGCTAAAAAACTTGGGATTCCTCGAAG
CCAGTTATTTGCAAAAGCATTAGAAGAATTTATCCAATCTCATAGTAAAGAATCTGTAACTGAGAAATTAAATAAAATCT
ACAGTAATAAATCCAAAGAAACTAGAAATAATATTACTGACTTATCCGTAGAATCGCTTCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q72T28

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HD92

References