Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4087309..4087981 Replicon chromosome
Accession NC_005810
Organism Yersinia pestis biovar Microtus str. 91001

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag YP_RS18765 Protein ID WP_002215144.1
Coordinates 4087309..4087734 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag YP_RS18770 Protein ID WP_002209939.1
Coordinates 4087715..4087981 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YP_RS18745 4082982..4083500 + 519 WP_002209934.1 flavodoxin FldB -
YP_RS18750 4083590..4085047 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
YP_RS18755 4085168..4086586 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
YP_RS18760 4086611..4087309 - 699 WP_002209937.1 two-component system response regulator CreB -
YP_RS18765 4087309..4087734 - 426 WP_002215144.1 protein YgfX Toxin
YP_RS18770 4087715..4087981 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
YP_RS18775 4088298..4089290 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
YP_RS18780 4089363..4089860 - 498 WP_002209941.1 DUF2165 family protein -
YP_RS18785 4090118..4090819 - 702 WP_002209942.1 hemolysin III family protein -
YP_RS18790 4091021..4092124 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T21051 WP_002215144.1 NC_005810:c4087734-4087309 [Yersinia pestis biovar Microtus str. 91001]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T21051 NC_005810:c4087734-4087309 [Yersinia pestis biovar Microtus str. 91001]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT21051 WP_002209939.1 NC_005810:c4087981-4087715 [Yersinia pestis biovar Microtus str. 91001]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT21051 NC_005810:c4087981-4087715 [Yersinia pestis biovar Microtus str. 91001]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References