Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2378232..2379198 Replicon chromosome
Accession NC_005810
Organism Yersinia pestis biovar Microtus str. 91001

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag YP_RS11085 Protein ID WP_002210981.1
Coordinates 2378740..2379198 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag YP_RS11080 Protein ID WP_002210982.1
Coordinates 2378232..2378678 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YP_RS11060 2373821..2374795 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
YP_RS11065 2374958..2375461 + 504 WP_002210984.1 thiol peroxidase -
YP_RS11070 2375714..2376172 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
YP_RS11075 2376319..2377896 - 1578 WP_002230917.1 transcriptional regulator TyrR -
YP_RS11080 2378232..2378678 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
YP_RS11085 2378740..2379198 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
YP_RS11090 2379208..2380269 - 1062 WP_002210980.1 YcjF family protein -
YP_RS11095 2380266..2381663 - 1398 WP_002210979.1 YcjX family protein -
YP_RS11100 2381644..2381886 - 243 WP_002216375.1 phage shock protein PspD -
YP_RS11105 2381971..2382330 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
YP_RS11110 2382330..2382557 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
YP_RS11115 2382719..2383384 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2375714..2376172 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T21049 WP_002210981.1 NC_005810:2378740-2379198 [Yersinia pestis biovar Microtus str. 91001]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T21049 NC_005810:2378740-2379198 [Yersinia pestis biovar Microtus str. 91001]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT21049 WP_002210982.1 NC_005810:2378232-2378678 [Yersinia pestis biovar Microtus str. 91001]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT21049 NC_005810:2378232-2378678 [Yersinia pestis biovar Microtus str. 91001]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References