Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2363913..2364551 Replicon chromosome
Accession NZ_CP079991
Organism Escherichia coli strain KMS2005

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KYK86_RS11470 Protein ID WP_000813794.1
Coordinates 2363913..2364089 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KYK86_RS11475 Protein ID WP_001270286.1
Coordinates 2364135..2364551 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYK86_RS11450 (2359532) 2359532..2360707 - 1176 WP_001236265.1 BenE family transporter YdcO -
KYK86_RS11455 (2360799) 2360799..2361335 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KYK86_RS11460 (2361408) 2361408..2363369 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KYK86_RS11465 (2363461) 2363461..2363691 - 231 WP_000494244.1 YncJ family protein -
KYK86_RS11470 (2363913) 2363913..2364089 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KYK86_RS11475 (2364135) 2364135..2364551 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KYK86_RS11480 (2364630) 2364630..2366036 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KYK86_RS11485 (2366281) 2366281..2367426 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KYK86_RS11490 (2367444) 2367444..2368457 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
KYK86_RS11495 (2368458) 2368458..2369399 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-57)

Antitoxin

(91-134)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T210461 WP_000813794.1 NZ_CP079991:2363913-2364089 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T210461 NZ_CP104523:c2911120-2910866 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT210461 WP_001270286.1 NZ_CP079991:2364135-2364551 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT210461 NZ_CP104523:c2911368-2911117 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6HPB


Antitoxin

Source ID Structure

References