Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2031533..2032042 Replicon chromosome
Accession NZ_CP079984
Organism Macrococcus bohemicus strain 19Msa0383

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KYI13_RS10745 Protein ID WP_096078043.1
Coordinates 2031533..2031895 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KYI13_RS10750 Protein ID WP_219497702.1
Coordinates 2031896..2032042 (-) Length 49 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI13_RS10720 (KYI13_10725) 2026609..2028759 - 2151 WP_203545786.1 Tex family protein -
KYI13_RS10725 (KYI13_10730) 2028840..2029607 - 768 WP_203545787.1 RNA polymerase sigma factor SigB -
KYI13_RS10730 (KYI13_10735) 2029618..2030058 - 441 WP_188018607.1 anti-sigma B factor RsbW -
KYI13_RS10735 (KYI13_10740) 2030060..2030386 - 327 WP_096078045.1 anti-sigma factor antagonist -
KYI13_RS10740 (KYI13_10745) 2030476..2031483 - 1008 WP_203545788.1 PP2C family protein-serine/threonine phosphatase -
KYI13_RS10745 (KYI13_10750) 2031533..2031895 - 363 WP_096078043.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KYI13_RS10750 (KYI13_10755) 2031896..2032042 - 147 WP_219497702.1 hypothetical protein Antitoxin
KYI13_RS10755 (KYI13_10760) 2032105..2033250 - 1146 WP_219497704.1 alanine racemase -
KYI13_RS10760 (KYI13_10765) 2033307..2033645 - 339 WP_096078041.1 holo-ACP synthase -
KYI13_RS10765 (KYI13_10770) 2033638..2034117 - 480 WP_096078040.1 PH domain-containing protein -
KYI13_RS10770 (KYI13_10775) 2034110..2035615 - 1506 WP_219497706.1 PH domain-containing protein -
KYI13_RS10775 (KYI13_10780) 2035602..2036081 - 480 WP_219497708.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13231.30 Da        Isoelectric Point: 7.3168

>T210448 WP_096078043.1 NZ_CP079984:c2031895-2031533 [Macrococcus bohemicus]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNDIGNKYSPTVIVAAITAKINKSKIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTYLPKEKMEEVDAALAISLNLSIDDSETLG

Download         Length: 363 bp

>T210448 NZ_CP104523:279357-279530 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 49 a.a.        Molecular weight: 5544.23 Da        Isoelectric Point: 3.9197

>AT210448 WP_219497702.1 NZ_CP079984:c2032042-2031896 [Macrococcus bohemicus]
MSKLLEQQLIEGYQSMAEINLLIASEHYLLECEVYDNVDHMSVKNDGE

Download         Length: 147 bp

>AT210448 NZ_CP104523:279033-279329 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAGTTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References