Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2087940..2088449 Replicon chromosome
Accession NZ_CP079981
Organism Macrococcus bohemicus strain 19Msa0936

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KYI11_RS11050 Protein ID WP_096078043.1
Coordinates 2087940..2088302 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KYI11_RS11055 Protein ID WP_165958642.1
Coordinates 2088303..2088449 (-) Length 49 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI11_RS11025 (KYI11_11035) 2083016..2085166 - 2151 WP_219502982.1 Tex family protein -
KYI11_RS11030 (KYI11_11040) 2085247..2086014 - 768 WP_096078047.1 RNA polymerase sigma factor SigB -
KYI11_RS11035 (KYI11_11045) 2086025..2086465 - 441 WP_188018607.1 anti-sigma B factor RsbW -
KYI11_RS11040 (KYI11_11050) 2086467..2086793 - 327 WP_096078045.1 anti-sigma factor antagonist -
KYI11_RS11045 (KYI11_11055) 2086883..2087890 - 1008 WP_096078044.1 PP2C family protein-serine/threonine phosphatase -
KYI11_RS11050 (KYI11_11060) 2087940..2088302 - 363 WP_096078043.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KYI11_RS11055 (KYI11_11065) 2088303..2088449 - 147 WP_165958642.1 hypothetical protein Antitoxin
KYI11_RS11060 (KYI11_11070) 2088512..2089657 - 1146 WP_203545789.1 alanine racemase -
KYI11_RS11065 (KYI11_11075) 2089714..2090052 - 339 WP_203545790.1 holo-ACP synthase -
KYI11_RS11070 (KYI11_11080) 2090045..2090524 - 480 WP_096078040.1 PH domain-containing protein -
KYI11_RS11075 (KYI11_11085) 2090517..2092022 - 1506 WP_219497706.1 PH domain-containing protein -
KYI11_RS11080 (KYI11_11090) 2092009..2092488 - 480 WP_219502986.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13231.30 Da        Isoelectric Point: 7.3168

>T210445 WP_096078043.1 NZ_CP079981:c2088302-2087940 [Macrococcus bohemicus]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNDIGNKYSPTVIVAAITAKINKSKIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTYLPKEKMEEVDAALAISLNLSIDDSETLG

Download         Length: 363 bp

>T210445 NZ_CP104521:c4526269-4526162 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 49 a.a.        Molecular weight: 5544.19 Da        Isoelectric Point: 3.7510

>AT210445 WP_165958642.1 NZ_CP079981:c2088449-2088303 [Macrococcus bohemicus]
MSKLLEQQLIEGYQSMAEINLLIASEHYLLECEVYDNVDHMSVQNDGE

Download         Length: 147 bp

>AT210445 NZ_CP104521:4526317-4526383 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References