Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1856196..1856687 Replicon chromosome
Accession NZ_CP079965
Organism Macrococcus caseolyticus strain 19Msa0687

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KYI09_RS09750 Protein ID WP_086039219.1
Coordinates 1856196..1856546 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KYI09_RS09755 Protein ID WP_101031708.1
Coordinates 1856547..1856687 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI09_RS09725 (KYI09_09730) 1851302..1853437 - 2136 WP_219521392.1 Tex family protein -
KYI09_RS09730 (KYI09_09735) 1853514..1854281 - 768 WP_101035471.1 RNA polymerase sigma factor SigB -
KYI09_RS09735 (KYI09_09740) 1854286..1854729 - 444 WP_101035470.1 anti-sigma B factor RsbW -
KYI09_RS09740 (KYI09_09745) 1854734..1855057 - 324 WP_101141627.1 anti-sigma factor antagonist -
KYI09_RS09745 (KYI09_09750) 1855140..1856147 - 1008 WP_133433326.1 PP2C family protein-serine/threonine phosphatase -
KYI09_RS09750 (KYI09_09755) 1856196..1856546 - 351 WP_086039219.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KYI09_RS09755 (KYI09_09760) 1856547..1856687 - 141 WP_101031708.1 antitoxin MazE Antitoxin
KYI09_RS09760 (KYI09_09765) 1856748..1857890 - 1143 WP_219521394.1 alanine racemase -
KYI09_RS09765 (KYI09_09770) 1857916..1858272 - 357 WP_219521396.1 holo-ACP synthase -
KYI09_RS09770 (KYI09_09775) 1858214..1858735 - 522 WP_219521400.1 PH domain-containing protein -
KYI09_RS09775 (KYI09_09780) 1858719..1860230 - 1512 WP_219521404.1 PH domain-containing protein -
KYI09_RS09780 (KYI09_09785) 1860220..1860696 - 477 WP_101141640.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12706.90 Da        Isoelectric Point: 10.1643

>T210441 WP_086039219.1 NZ_CP079965:c1856546-1856196 [Macrococcus caseolyticus]
MKRGDVFLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKATHRLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T210441 NZ_CP104521:c4382919-4382542 [Escherichia coli]
ATGACCATTCAGTTTATCTCAGCGGAGGAGATAATTTATTTCCACGATAAATTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTATGAGTATGAAGGCGTTTCTGATCTTT
GGTTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATCTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCATCATACTTGCTGCAAACCCAGAGTTTGTAGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACGCGGTACCTGA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5326.88 Da        Isoelectric Point: 3.8301

>AT210441 WP_101031708.1 NZ_CP079965:c1856687-1856547 [Macrococcus caseolyticus]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNHQTYTFDGE

Download         Length: 141 bp

>AT210441 NZ_CP104521:c4383137-4382916 [Escherichia coli]
ATGCATACCATGAACTACAGCGAAGCGCGGCAGAACCTTGCATTAGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCAGCTGTGATTATCAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CAGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTAAGGAGTTAGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References