Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1856107..1856598 Replicon chromosome
Accession NZ_CP079955
Organism Macrococcus sp. 19Msa1099

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KYI10_RS09905 Protein ID WP_101141631.1
Coordinates 1856107..1856457 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KYI10_RS09910 Protein ID WP_099482357.1
Coordinates 1856458..1856598 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI10_RS09880 (KYI10_09875) 1851215..1853350 - 2136 WP_219493138.1 Tex family protein -
KYI10_RS09885 (KYI10_09880) 1853427..1854194 - 768 WP_219493140.1 RNA polymerase sigma factor SigB -
KYI10_RS09890 (KYI10_09885) 1854199..1854642 - 444 WP_101141625.1 anti-sigma B factor RsbW -
KYI10_RS09895 (KYI10_09890) 1854647..1854970 - 324 WP_101141627.1 anti-sigma factor antagonist -
KYI10_RS09900 (KYI10_09895) 1855051..1856058 - 1008 WP_219493142.1 PP2C family protein-serine/threonine phosphatase -
KYI10_RS09905 (KYI10_09900) 1856107..1856457 - 351 WP_101141631.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KYI10_RS09910 (KYI10_09905) 1856458..1856598 - 141 WP_099482357.1 antitoxin MazE Antitoxin
KYI10_RS09915 (KYI10_09910) 1856659..1857801 - 1143 WP_219493143.1 alanine racemase -
KYI10_RS09920 (KYI10_09915) 1857827..1858183 - 357 WP_101141634.1 holo-ACP synthase -
KYI10_RS09925 (KYI10_09920) 1858125..1858646 - 522 WP_219493144.1 PH domain-containing protein -
KYI10_RS09930 (KYI10_09925) 1858630..1860141 - 1512 WP_219493145.1 PH domain-containing protein -
KYI10_RS09935 (KYI10_09930) 1860131..1860607 - 477 WP_219493146.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12726.89 Da        Isoelectric Point: 10.1643

>T210439 WP_101141631.1 NZ_CP079955:c1856457-1856107 [Macrococcus sp. 19Msa1099]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTTHRLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T210439 NZ_CP104521:3884183-3884557 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5352.91 Da        Isoelectric Point: 3.6323

>AT210439 WP_099482357.1 NZ_CP079955:c1856598-1856458 [Macrococcus sp. 19Msa1099]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNYQTYTFDGE

Download         Length: 141 bp

>AT210439 NZ_CP104521:3883725-3884093 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References