210436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2019009..2019500 Replicon chromosome
Accession NZ_CP079950
Organism Macrococcus caseolyticus strain 19Msa0287

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KYI08_RS10760 Protein ID WP_041636190.1
Coordinates 2019009..2019359 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KYI08_RS10765 Protein ID WP_101031708.1
Coordinates 2019360..2019500 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI08_RS10735 (KYI08_10735) 2014113..2016248 - 2136 WP_101057565.1 Tex family protein -
KYI08_RS10740 (KYI08_10740) 2016325..2017092 - 768 WP_015912228.1 RNA polymerase sigma factor SigB -
KYI08_RS10745 (KYI08_10745) 2017097..2017540 - 444 WP_015912229.1 anti-sigma B factor RsbW -
KYI08_RS10750 (KYI08_10750) 2017545..2017868 - 324 WP_015912230.1 anti-sigma factor antagonist -
KYI08_RS10755 (KYI08_10755) 2017953..2018960 - 1008 WP_101142542.1 PP2C family protein-serine/threonine phosphatase -
KYI08_RS10760 (KYI08_10760) 2019009..2019359 - 351 WP_041636190.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KYI08_RS10765 (KYI08_10765) 2019360..2019500 - 141 WP_101031708.1 antitoxin MazE Antitoxin
KYI08_RS10770 (KYI08_10770) 2019561..2020703 - 1143 WP_101057569.1 alanine racemase -
KYI08_RS10775 (KYI08_10775) 2020729..2021085 - 357 WP_086039221.1 holo-ACP synthase -
KYI08_RS10780 (KYI08_10780) 2021027..2021548 - 522 WP_157819859.1 PH domain-containing protein -
KYI08_RS10785 (KYI08_10785) 2021532..2023043 - 1512 WP_101035466.1 PH domain-containing protein -
KYI08_RS10790 (KYI08_10790) 2023033..2023509 - 477 WP_041636191.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12687.86 Da        Isoelectric Point: 9.9422

>T210436 WP_041636190.1 NZ_CP079950:c2019359-2019009 [Macrococcus caseolyticus]
MKRGDVFLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKATHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T210436 NZ_CP104521:c2743293-2743042 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5326.88 Da        Isoelectric Point: 3.8301

>AT210436 WP_101031708.1 NZ_CP079950:c2019500-2019360 [Macrococcus caseolyticus]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNHQTYTFDGE

Download         Length: 141 bp

>AT210436 NZ_CP104521:c2743045-2742791 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATTATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References