Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3085094..3085747 Replicon chromosome
Accession NZ_CP079944
Organism Acinetobacter baumannii strain 04117201 isolate DstkR-2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KYX49_RS14705 Protein ID WP_000607077.1
Coordinates 3085094..3085483 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KYX49_RS14710 Protein ID WP_001288210.1
Coordinates 3085490..3085747 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX49_RS14690 (KYX49_14585) 3080212..3082407 - 2196 WP_001158906.1 TRAP transporter large permease subunit -
KYX49_RS14695 (KYX49_14590) 3082595..3083161 - 567 WP_000651538.1 rhombosortase -
KYX49_RS14700 (KYX49_14595) 3083239..3084324 - 1086 WP_000049106.1 hypothetical protein -
KYX49_RS14705 (KYX49_14600) 3085094..3085483 - 390 WP_000607077.1 membrane protein Toxin
KYX49_RS14710 (KYX49_14605) 3085490..3085747 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KYX49_RS14715 (KYX49_14610) 3085935..3087107 + 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
KYX49_RS14720 (KYX49_14615) 3087156..3088646 - 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
KYX49_RS14725 (KYX49_14620) 3088828..3089205 - 378 WP_001216380.1 50S ribosomal protein L17 -
KYX49_RS14730 (KYX49_14625) 3089224..3090231 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T210434 WP_000607077.1 NZ_CP079944:c3085483-3085094 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T210434 NZ_CP104521:c2520284-2520182 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT210434 WP_001288210.1 NZ_CP079944:c3085747-3085490 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT210434 NZ_CP104521:2520144-2520412 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References