Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HTH_37(antitoxin)
Location 4718003..4718671 Replicon chromosome
Accession NZ_CP079940
Organism Achromobacter sp. ES-001

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KYT87_RS21305 Protein ID WP_219990810.1
Coordinates 4718003..4718188 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KYT87_RS21310 Protein ID WP_046806866.1
Coordinates 4718258..4718671 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYT87_RS21280 (KYT87_21280) 4713054..4713794 - 741 WP_219990806.1 Clp protease ClpP -
KYT87_RS21285 (KYT87_21285) 4713757..4715100 - 1344 WP_219990807.1 phage portal protein -
KYT87_RS21290 (KYT87_21290) 4715100..4716800 - 1701 WP_219990808.1 terminase large subunit -
KYT87_RS21295 (KYT87_21295) 4716847..4717167 - 321 WP_127185228.1 hypothetical protein -
KYT87_RS21300 (KYT87_21300) 4717438..4717809 - 372 WP_219990809.1 HNH endonuclease signature motif containing protein -
KYT87_RS21305 (KYT87_21305) 4718003..4718188 + 186 WP_219990810.1 type II toxin-antitoxin system HicA family toxin Toxin
KYT87_RS21310 (KYT87_21310) 4718258..4718671 + 414 WP_046806866.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KYT87_RS21315 (KYT87_21315) 4718686..4719051 + 366 WP_052946093.1 response regulator -
KYT87_RS21320 (KYT87_21320) 4719086..4719856 - 771 WP_219990811.1 DNA adenine methylase -
KYT87_RS21325 (KYT87_21325) 4720029..4720724 + 696 WP_219990812.1 hypothetical protein -
KYT87_RS21330 (KYT87_21330) 4720801..4721145 - 345 WP_046806869.1 hypothetical protein -
KYT87_RS21335 (KYT87_21335) 4721274..4721471 - 198 WP_219990813.1 hypothetical protein -
KYT87_RS21340 (KYT87_21340) 4721590..4722183 - 594 WP_219990814.1 hypothetical protein -
KYT87_RS21345 (KYT87_21345) 4722180..4722569 - 390 WP_219990815.1 hypothetical protein -
KYT87_RS21350 (KYT87_21350) 4722578..4722940 - 363 WP_052946097.1 hypothetical protein -
KYT87_RS21355 (KYT87_21355) 4722976..4723170 - 195 WP_046806873.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6879.06 Da        Isoelectric Point: 10.6579

>T210431 WP_219990810.1 NZ_CP079940:4718003-4718188 [Achromobacter sp. ES-001]
MKYSELRRWLLKQGVKLEPHKSGSSHFKATLGDLQTSFPDHGSKEIGMGLVQKIKKDLGLK

Download         Length: 186 bp

>T210431 NZ_CP104521:c1899898-1899791 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15017.03 Da        Isoelectric Point: 4.6251

>AT210431 WP_046806866.1 NZ_CP079940:4718258-4718671 [Achromobacter sp. ES-001]
MLTYCYTLTPDTNGTNLIQYPDLPEGASVSEDEHDLQANASEGLEAVLQMYIDARRPIPLPEAVGDGSVTLGALPTAKVF
LSNEMVRQGVRKTELARRLGIHNPQVDRLLDLAHSSKLEAMEAAFRELGRRLDISVA

Download         Length: 414 bp

>AT210431 NZ_CP104521:1899951-1900012 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References