Detailed information of TA system TA210430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4417732..4418328
• Replicon: chromosome
• Accession: NZ_CP079940
• Organism: Achromobacter sp. ES-001

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KYT87_RS19880
• Protein ID: WP_082134483.1
• Coordinates: 4417732..4417914 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KYT87_RS19885
• Protein ID: WP_219990664.1
• Coordinates: 4417939..4418328 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYT87_RS19855 (KYT87_19855)	4412999..4413574	+	576	WP_219990661.1	TRAP transporter small permease	-
KYT87_RS19860 (KYT87_19860)	4413571..4414851	+	1281	WP_104144064.1	TRAP transporter large permease subunit	-
KYT87_RS19865 (KYT87_19865)	4414941..4415642	+	702	WP_046804879.1	protocatechuate 3,4-dioxygenase subunit beta	-
KYT87_RS19870 (KYT87_19870)	4415646..4416221	+	576	WP_219990662.1	protocatechuate 3,4-dioxygenase subunit alpha	-
KYT87_RS19875 (KYT87_19875)	4416244..4417626	+	1383	WP_219990663.1	3-carboxy-cis,cis-muconate cycloisomerase	-
KYT87_RS19880 (KYT87_19880)	4417732..4417914	+	183	WP_082134483.1	type II toxin-antitoxin system HicA family toxin	Toxin
KYT87_RS19885 (KYT87_19885)	4417939..4418328	+	390	WP_219990664.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KYT87_RS19890 (KYT87_19890)	4418411..4418794	+	384	WP_219990665.1	GFA family protein	-
KYT87_RS19895 (KYT87_19895)	4418791..4419105	+	315	WP_120156467.1	hypothetical protein	-
KYT87_RS19905 (KYT87_19905)	4419465..4420049	-	585	WP_219990666.1	XRE family transcriptional regulator	-
KYT87_RS19910 (KYT87_19910)	4420063..4421355	-	1293	WP_219990667.1	FAD-dependent oxidoreductase	-
KYT87_RS19915 (KYT87_19915)	4421372..4422061	-	690	WP_046804863.1	amino acid ABC transporter permease	-
KYT87_RS19920 (KYT87_19920)	4422064..4422756	-	693	WP_046804862.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6770.92 Da
• Isoelectric Point: 11.4487

>T210430 WP_082134483.1 NZ_CP079940:4417732-4417914 [Achromobacter sp. ES-001]
MNSADIIKRLKADGWYLVHTVGSHHQFKHPTKRGKVTVPHPRKDLPVPTAHSILKQAGLR

Nucleotide

• Length: 183 bp

>T210430 NZ_CP104521:c1784214-1783720 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGATCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14098.29 Da
• Isoelectric Point: 8.9632

>AT210430 WP_219990664.1 NZ_CP079940:4417939-4418328 [Achromobacter sp. ES-001]
MLYPIYVHKEKSSAYGASFPDFPGCHAAATTLQRLPAAAQEAVEAHFFGETAPIAPPTAPEVWIQKKAFKGGFWMLVDID
LSKVNAKAVRLNISLPENLVHRIDAVARARRLSRSAFLALAAQHEMEAA

Nucleotide

• Length: 390 bp

>AT210430 NZ_CP104521:c1784504-1784211 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTATCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA