Detailed information of TA system TA210429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2779348..2780015
• Replicon: chromosome
• Accession: NZ_CP079940
• Organism: Achromobacter sp. ES-001

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KYT87_RS12600
• Protein ID: WP_219992378.1
• Coordinates: 2779348..2779767 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2S5GS07
• Locus tag: KYT87_RS12605
• Protein ID: WP_046807503.1
• Coordinates: 2779764..2780015 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYT87_RS12575 (KYT87_12575)	2774460..2775419	-	960	WP_219992375.1	DMT family transporter	-
KYT87_RS12580 (KYT87_12580)	2775582..2776460	-	879	WP_255594090.1	AraC family transcriptional regulator	-
KYT87_RS12585 (KYT87_12585)	2776827..2778101	-	1275	WP_219992376.1	RNA polymerase sigma factor	-
KYT87_RS12590 (KYT87_12590)	2778098..2778550	-	453	WP_255594091.1	VOC family protein	-
KYT87_RS12595 (KYT87_12595)	2778591..2779001	-	411	WP_219992377.1	YciI family protein	-
KYT87_RS12600 (KYT87_12600)	2779348..2779767	-	420	WP_219992378.1	type II toxin-antitoxin system VapC family toxin	Toxin
KYT87_RS12605 (KYT87_12605)	2779764..2780015	-	252	WP_046807503.1	Arc family DNA-binding protein	Antitoxin
KYT87_RS12610 (KYT87_12610)	2780112..2780465	-	354	WP_120155297.1	YciI family protein	-
KYT87_RS12615 (KYT87_12615)	2780624..2781688	-	1065	WP_219992379.1	OmpA family protein	-
KYT87_RS12620 (KYT87_12620)	2781685..2782575	-	891	WP_219992380.1	MotA/TolQ/ExbB proton channel family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (11-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14618.75 Da
• Isoelectric Point: 5.0174

>T210429 WP_219992378.1 NZ_CP079940:c2779767-2779348 [Achromobacter sp. ES-001]
MILLDTNVISEPLRQAPSDAVIAWIDRQPLETLFLSAVTVAELRFGVACMAAGKRRNVLQDSLEQQVLALFAGRVLSFDT
AASQQYAALMARARASGQAIAAADGYIAATAAAHGMSVATRDVAPFTAAGVSVIDPWQS

Nucleotide

• Length: 420 bp

>T210429 NZ_CP104521:c1537507-1537121 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 10.2879

>AT210429 WP_046807503.1 NZ_CP079940:c2780015-2779764 [Achromobacter sp. ES-001]
MPMLTVRNISDEVHRALRVRAAQHGRSTEAEVRAILEDAVKPEGRVKLGSLLARIGNQAKLTDQEAALFDQRDKTPAAPP
RFE

Nucleotide

• Length: 252 bp

>AT210429 NZ_CP104521:c1537131-1536802 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2S5GS07