Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1334858..1335492 Replicon chromosome
Accession NZ_CP079940
Organism Achromobacter sp. ES-001

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KYT87_RS05965 Protein ID WP_219991841.1
Coordinates 1335310..1335492 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KYT87_RS05960 Protein ID WP_219991840.1
Coordinates 1334858..1335250 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYT87_RS05940 (KYT87_05940) 1330250..1331770 - 1521 WP_219992601.1 sensor histidine kinase -
KYT87_RS05945 (KYT87_05945) 1331773..1332477 - 705 WP_219991839.1 response regulator transcription factor -
KYT87_RS05950 (KYT87_05950) 1332668..1334008 + 1341 WP_104142927.1 CitMHS family transporter -
KYT87_RS05955 (KYT87_05955) 1334045..1334785 + 741 WP_104142929.1 SDR family oxidoreductase -
KYT87_RS05960 (KYT87_05960) 1334858..1335250 - 393 WP_219991840.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KYT87_RS05965 (KYT87_05965) 1335310..1335492 - 183 WP_219991841.1 type II toxin-antitoxin system HicA family toxin Toxin
KYT87_RS05970 (KYT87_05970) 1335612..1335953 + 342 WP_046802511.1 hypothetical protein -
KYT87_RS05975 (KYT87_05975) 1335992..1336438 - 447 WP_104142933.1 hypothetical protein -
KYT87_RS05980 (KYT87_05980) 1336917..1337120 + 204 WP_006217928.1 cold-shock protein -
KYT87_RS05985 (KYT87_05985) 1337161..1337418 + 258 WP_046802513.1 hypothetical protein -
KYT87_RS05990 (KYT87_05990) 1337532..1338449 + 918 WP_046802514.1 DUF808 domain-containing protein -
KYT87_RS05995 (KYT87_05995) 1338725..1339594 + 870 WP_219991842.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6730.04 Da        Isoelectric Point: 11.3078

>T210428 WP_219991841.1 NZ_CP079940:c1335492-1335310 [Achromobacter sp. ES-001]
MDSREIIRQLRLAGWVYRNARGLQHIYVHPPKPGHISVPHPKKDLGIGLVAKLLTLAGLK

Download         Length: 183 bp

>T210428 NZ_CP104521:1172971-1173273 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13807.58 Da        Isoelectric Point: 4.1342

>AT210428 WP_219991840.1 NZ_CP079940:c1335250-1334858 [Achromobacter sp. ES-001]
MKYPIAIEPDSDTQAWGVVVPDLPGCYSASDTGIDDAIESAKEAIALWIETALDTGAAVPPPGSIAAHQANPEFAGWVWA
IVDIDPAVMDDTIERVNITLPRRILARIDAKARAAGESRSGYIAQLALTH

Download         Length: 393 bp

>AT210428 NZ_CP104521:1173309-1173650 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References