Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3688903..3689560 Replicon chromosome
Accession NZ_CP079939
Organism Enterobacter hormaechei strain G17

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag KY275_RS19485 Protein ID WP_017382887.1
Coordinates 3688903..3689313 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag KY275_RS19490 Protein ID WP_003863437.1
Coordinates 3689294..3689560 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY275_RS19465 (KY275_19470) 3684901..3686634 - 1734 WP_213789000.1 single-stranded-DNA-specific exonuclease RecJ -
KY275_RS19470 (KY275_19475) 3686640..3687353 - 714 WP_121478608.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KY275_RS19475 (KY275_19480) 3687382..3688278 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
KY275_RS19480 (KY275_19485) 3688380..3688901 + 522 WP_015571793.1 flavodoxin FldB -
KY275_RS19485 (KY275_19490) 3688903..3689313 - 411 WP_017382887.1 protein YgfX Toxin
KY275_RS19490 (KY275_19495) 3689294..3689560 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
KY275_RS19495 (KY275_19500) 3689855..3690835 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
KY275_RS19500 (KY275_19505) 3690947..3691606 - 660 WP_003863433.1 hemolysin III family protein -
KY275_RS19505 (KY275_19510) 3691873..3692604 + 732 WP_047050802.1 MurR/RpiR family transcriptional regulator -
KY275_RS19510 (KY275_19515) 3692721..3694154 + 1434 WP_032660252.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T210425 WP_017382887.1 NZ_CP079939:c3689313-3688903 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T210425 NZ_CP104521:477610-477987 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT210425 WP_003863437.1 NZ_CP079939:c3689560-3689294 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT210425 NZ_CP104521:477152-477520 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References