Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2242107..2242846 Replicon chromosome
Accession NZ_CP079939
Organism Enterobacter hormaechei strain G17

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag KY275_RS12605 Protein ID WP_003857133.1
Coordinates 2242107..2242592 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag KY275_RS12610 Protein ID WP_003857131.1
Coordinates 2242580..2242846 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY275_RS12580 (KY275_12585) 2238185..2239375 + 1191 WP_213788776.1 cytochrome c biogenesis protein/redoxin -
KY275_RS12585 (KY275_12590) 2239382..2240140 - 759 WP_063132717.1 trans-aconitate 2-methyltransferase -
KY275_RS12590 (KY275_12595) 2240225..2240338 - 114 Protein_2108 GDP-mannose pyrophosphatase -
KY275_RS12595 (KY275_12600) 2240341..2240532 + 192 Protein_2109 DeoR family transcriptional regulator -
KY275_RS12600 (KY275_12605) 2240637..2241929 + 1293 WP_213788777.1 glycosyl hydrolase family 28 protein -
KY275_RS12605 (KY275_12610) 2242107..2242592 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
KY275_RS12610 (KY275_12615) 2242580..2242846 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
KY275_RS12615 (KY275_12620) 2242910..2243839 - 930 WP_213788778.1 LysR family transcriptional regulator -
KY275_RS12620 (KY275_12625) 2243969..2245357 + 1389 WP_213788839.1 MFS transporter -
KY275_RS12625 (KY275_12630) 2245379..2246374 - 996 WP_015570513.1 DUF2891 domain-containing protein -
KY275_RS12630 (KY275_12635) 2246384..2247370 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T210416 WP_003857133.1 NZ_CP079939:c2242592-2242107 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T210416 NZ_CP104516:3956926-3957222 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT210416 WP_003857131.1 NZ_CP079939:c2242846-2242580 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT210416 NZ_CP104516:3957224-3957619 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References