Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1067385..1068005 Replicon chromosome
Accession NZ_CP079939
Organism Enterobacter hormaechei strain G17

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag KY275_RS06895 Protein ID WP_015571250.1
Coordinates 1067385..1067603 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag KY275_RS06900 Protein ID WP_006809850.1
Coordinates 1067631..1068005 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY275_RS06865 (KY275_06870) 1063414..1063674 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
KY275_RS06870 (KY275_06875) 1063677..1063817 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KY275_RS06875 (KY275_06880) 1063814..1064524 - 711 WP_062932282.1 GNAT family protein -
KY275_RS06880 (KY275_06885) 1064626..1066069 + 1444 Protein_978 PLP-dependent aminotransferase family protein -
KY275_RS06885 (KY275_06890) 1066041..1066508 - 468 WP_213788937.1 YlaC family protein -
KY275_RS06890 (KY275_06895) 1066625..1067176 - 552 WP_017694396.1 maltose O-acetyltransferase -
KY275_RS06895 (KY275_06900) 1067385..1067603 - 219 WP_015571250.1 HHA domain-containing protein Toxin
KY275_RS06900 (KY275_06905) 1067631..1068005 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
KY275_RS06905 (KY275_06910) 1068514..1071660 - 3147 WP_023296042.1 multidrug efflux RND transporter permease subunit AcrB -
KY275_RS06910 (KY275_06915) 1071683..1072876 - 1194 WP_193136217.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T210415 WP_015571250.1 NZ_CP079939:c1067603-1067385 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T210415 NZ_CP104516:3892352-3892666 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT210415 WP_006809850.1 NZ_CP079939:c1068005-1067631 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT210415 NZ_CP104516:3892663-3893079 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References