Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 60849..61511 Replicon chromosome
Accession NZ_CP079939
Organism Enterobacter hormaechei strain G17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KY275_RS02115 Protein ID WP_080454685.1
Coordinates 61113..61511 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KY275_RS02110 Protein ID WP_047050676.1
Coordinates 60849..61109 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY275_RS02085 (KY275_02090) 56066..57187 - 1122 WP_017383665.1 efflux RND transporter periplasmic adaptor subunit -
KY275_RS02090 (KY275_02095) 57335..57904 - 570 WP_000104919.1 TetR/AcrR family transcriptional regulator -
KY275_RS02095 (KY275_02100) 58090..58509 + 420 WP_213789105.1 GNAT family N-acetyltransferase -
KY275_RS02100 (KY275_02105) 58506..59153 - 648 WP_062933088.1 TetR/AcrR family transcriptional regulator -
KY275_RS02105 (KY275_02110) 59247..60731 + 1485 WP_017693997.1 MDR family MFS transporter -
KY275_RS02110 (KY275_02115) 60849..61109 + 261 WP_047050676.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KY275_RS02115 (KY275_02120) 61113..61511 + 399 WP_080454685.1 type II toxin-antitoxin system VapC family toxin Toxin
KY275_RS02120 (KY275_02125) 61701..62501 + 801 WP_023315104.1 lipoprotein NlpA -
KY275_RS02125 (KY275_02130) 62535..63215 - 681 WP_047364897.1 EAL domain-containing protein -
KY275_RS02130 (KY275_02135) 63291..64034 - 744 WP_235143903.1 LuxR C-terminal-related transcriptional regulator -
KY275_RS02135 (KY275_02140) 64451..65116 + 666 WP_074135696.1 LuxR C-terminal-related transcriptional regulator -
KY275_RS02140 (KY275_02145) 65123..66187 - 1065 WP_047050683.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14702.84 Da        Isoelectric Point: 5.5038

>T210414 WP_080454685.1 NZ_CP079939:61113-61511 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAATYGE
LRAAMEKKGNVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTTVA

Download         Length: 399 bp

>T210414 NZ_CP104516:3429300-3429407 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10084.38 Da        Isoelectric Point: 9.6899

>AT210414 WP_047050676.1 NZ_CP079939:60849-61109 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Download         Length: 261 bp

>AT210414 NZ_CP104516:c3429252-3429186 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References