210412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5480..6068 Replicon plasmid pAB2
Accession NZ_CP079934
Organism Acinetobacter baumannii strain 17978UN

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag KZA74_RS19415 Protein ID WP_000438826.1
Coordinates 5480..5767 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A858UV00
Locus tag KZA74_RS19420 Protein ID WP_061855757.1
Coordinates 5754..6068 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZA74_RS19380 (KZA74_19390) 944..1519 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
KZA74_RS19385 (KZA74_19395) 1539..1682 + 144 WP_001125244.1 hypothetical protein -
KZA74_RS19390 (KZA74_19400) 1867..2070 - 204 WP_000482656.1 hypothetical protein -
KZA74_RS19395 (KZA74_19405) 2314..2559 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KZA74_RS19400 (KZA74_19410) 2549..2842 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin -
KZA74_RS19405 (KZA74_19415) 3060..4262 + 1203 WP_061855756.1 alpha/beta fold hydrolase -
KZA74_RS19410 (KZA74_19420) 4360..5133 + 774 WP_061855758.1 glucose 1-dehydrogenase -
KZA74_RS19415 (KZA74_19425) 5480..5767 + 288 WP_000438826.1 BrnT family toxin Toxin
KZA74_RS19420 (KZA74_19430) 5754..6068 + 315 WP_061855757.1 BrnA antitoxin family protein Antitoxin
KZA74_RS19425 (KZA74_19435) 6197..8608 + 2412 WP_000932945.1 TonB-dependent receptor ZnuD2 -
KZA74_RS19430 (KZA74_19440) 8705..9403 + 699 WP_000007662.1 CPBP family glutamic-type intramembrane protease -
KZA74_RS19435 (KZA74_19445) 9525..9722 - 198 WP_001282483.1 hypothetical protein -
KZA74_RS19440 (KZA74_19450) 9722..10093 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11302 11302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T210412 WP_000438826.1 NZ_CP079934:5480-5767 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T210412 NZ_CP104516:3428334-3428441 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12227.88 Da        Isoelectric Point: 8.4628

>AT210412 WP_061855757.1 NZ_CP079934:5754-6068 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT210412 NZ_CP104516:c3428276-3428220 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB A0A858UV00

References