Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2314..2842 | Replicon | plasmid pAB2 |
| Accession | NZ_CP079934 | ||
| Organism | Acinetobacter baumannii strain 17978UN | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | N9N871 |
| Locus tag | KZA74_RS19400 | Protein ID | WP_000221358.1 |
| Coordinates | 2549..2842 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | N9B5Q7 |
| Locus tag | KZA74_RS19395 | Protein ID | WP_000246756.1 |
| Coordinates | 2314..2559 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZA74_RS19375 (KZA74_19385) | 1..951 | + | 951 | WP_001205343.1 | replication initiation protein RepM | - |
| KZA74_RS19380 (KZA74_19390) | 944..1519 | + | 576 | WP_001096616.1 | plasmid replication DNA-binding protein | - |
| KZA74_RS19385 (KZA74_19395) | 1539..1682 | + | 144 | WP_001125244.1 | hypothetical protein | - |
| KZA74_RS19390 (KZA74_19400) | 1867..2070 | - | 204 | WP_000482656.1 | hypothetical protein | - |
| KZA74_RS19395 (KZA74_19405) | 2314..2559 | + | 246 | WP_000246756.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KZA74_RS19400 (KZA74_19410) | 2549..2842 | + | 294 | WP_000221358.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KZA74_RS19405 (KZA74_19415) | 3060..4262 | + | 1203 | WP_061855756.1 | alpha/beta fold hydrolase | - |
| KZA74_RS19410 (KZA74_19420) | 4360..5133 | + | 774 | WP_061855758.1 | glucose 1-dehydrogenase | - |
| KZA74_RS19415 (KZA74_19425) | 5480..5767 | + | 288 | WP_000438826.1 | BrnT family toxin | - |
| KZA74_RS19420 (KZA74_19430) | 5754..6068 | + | 315 | WP_061855757.1 | BrnA antitoxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..11302 | 11302 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11292.52 Da Isoelectric Point: 10.4753
>T210411 WP_000221358.1 NZ_CP079934:2549-2842 [Acinetobacter baumannii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T210411 NZ_CP104516:3427851-3427958 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9235.61 Da Isoelectric Point: 4.3142
>AT210411 WP_000246756.1 NZ_CP079934:2314-2559 [Acinetobacter baumannii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
Download Length: 246 bp
>AT210411 NZ_CP104516:c3427794-3427737 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6A1RKP4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N9B5Q7 |