Detailed information of TA system TA210409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1913407..1915043
• Replicon: chromosome
• Accession: NZ_CP079931
• Organism: Acinetobacter baumannii strain 17978UN

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: KZA74_RS09075
• Protein ID: WP_000737056.1
• Coordinates: 1913407..1914738 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KZA74_RS09080
• Protein ID: WP_001101308.1
• Coordinates: 1914735..1915043 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZA74_RS09055 (KZA74_09065)	1909722..1910882	+	1161	WP_001044492.1	hypothetical protein	-
KZA74_RS09060 (KZA74_09070)	1911009..1911980	+	972	WP_109104914.1	5'/3'-nucleotidase SurE	-
KZA74_RS09065 (KZA74_09075)	1911992..1912636	+	645	WP_000817301.1	hypothetical protein	-
KZA74_RS09070 (KZA74_09080)	1912671..1913111	-	441	WP_000193135.1	HD domain-containing protein	-
KZA74_RS09075 (KZA74_09085)	1913407..1914738	+	1332	WP_000737056.1	HipA domain-containing protein	Toxin
KZA74_RS09080 (KZA74_09090)	1914735..1915043	+	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
KZA74_RS09085 (KZA74_09095)	1915769..1916320	+	552	WP_049594830.1	TetR/AcrR family transcriptional regulator	-
KZA74_RS09090 (KZA74_09100)	1916536..1917156	+	621	WP_000658761.1	hypothetical protein	-
KZA74_RS09095 (KZA74_09105)	1917174..1918256	+	1083	WP_001095788.1	XRE family transcriptional regulator	-
KZA74_RS09100 (KZA74_09110)	1918298..1918813	+	516	WP_000914805.1	hypothetical protein	-
KZA74_RS09105 (KZA74_09115)	1918961..1919479	+	519	WP_000651611.1	GNAT family N-acetyltransferase	-
KZA74_RS19505	1919460..1919591	+	132	Protein_1782	TetR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T210409 WP_000737056.1 NZ_CP079931:1913407-1914738 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T210409 NZ_CP104516:c2665817-2665644 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT210409 WP_001101308.1 NZ_CP079931:1914735-1915043 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT210409 NZ_CP104516:c2666141-2665845 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1