Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 457474..458127 Replicon chromosome
Accession NZ_CP079931
Organism Acinetobacter baumannii strain 17978UN

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag KZA74_RS02245 Protein ID WP_009518132.1
Coordinates 457738..458127 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KZA74_RS02240 Protein ID WP_001288210.1
Coordinates 457474..457731 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZA74_RS02220 (KZA74_02220) 452989..453996 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
KZA74_RS02225 (KZA74_02225) 454015..454392 + 378 WP_001216380.1 50S ribosomal protein L17 -
KZA74_RS02230 (KZA74_02230) 454574..456064 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
KZA74_RS02235 (KZA74_02235) 456114..457286 - 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
KZA74_RS02240 (KZA74_02240) 457474..457731 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KZA74_RS02245 (KZA74_02245) 457738..458127 + 390 WP_009518132.1 hypothetical protein Toxin
KZA74_RS02250 (KZA74_02250) 458897..459982 + 1086 WP_000049106.1 hypothetical protein -
KZA74_RS02255 (KZA74_02255) 460061..460627 + 567 WP_000651535.1 rhombosortase -
KZA74_RS02260 (KZA74_02260) 460815..463010 + 2196 WP_001158904.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T210407 WP_009518132.1 NZ_CP079931:457738-458127 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

>T210407 NZ_CP104516:2417320-2417577 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT210407 WP_001288210.1 NZ_CP079931:457474-457731 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT210407 NZ_CP104516:2417589-2418134 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References