Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3473973..3474561 Replicon chromosome
Accession NZ_CP079926
Organism Caulobacter vibrioides strain CB S2B lysogen

Toxin (Protein)


Gene name hicA Uniprot ID Q9A3L9
Locus tag KZH45_RS16875 Protein ID WP_010921020.1
Coordinates 3473973..3474161 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9A3L8
Locus tag KZH45_RS16880 Protein ID WP_010921021.1
Coordinates 3474166..3474561 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH45_RS16850 (KZH45_16845) 3469857..3470876 - 1020 WP_024265922.1 amidohydrolase family protein -
KZH45_RS16855 (KZH45_16850) 3471052..3472086 + 1035 WP_010921016.1 adenosine deaminase -
KZH45_RS16860 (KZH45_16855) 3472097..3473065 + 969 WP_010921017.1 magnesium and cobalt transport protein CorA -
KZH45_RS16865 (KZH45_16860) 3473043..3473594 - 552 WP_010921018.1 hypothetical protein -
KZH45_RS16870 (KZH45_16865) 3473591..3473896 - 306 WP_010921019.1 PadR family transcriptional regulator -
KZH45_RS16875 (KZH45_16870) 3473973..3474161 + 189 WP_010921020.1 type II toxin-antitoxin system HicA family toxin Toxin
KZH45_RS16880 (KZH45_16875) 3474166..3474561 + 396 WP_010921021.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KZH45_RS16885 (KZH45_16880) 3474570..3475046 - 477 WP_010921022.1 DUF2199 domain-containing protein -
KZH45_RS16890 (KZH45_16885) 3475104..3476102 - 999 WP_010921023.1 DegT/DnrJ/EryC1/StrS aminotransferase family protein -
KZH45_RS16895 (KZH45_16890) 3476230..3477783 - 1554 WP_010921024.1 class I adenylate-forming enzyme family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6984.02 Da        Isoelectric Point: 11.4778

>T210404 WP_010921020.1 NZ_CP079926:3473973-3474161 [Caulobacter vibrioides]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR

Download         Length: 189 bp

>T210404 NZ_CP104516:c1952253-1951876 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13937.84 Da        Isoelectric Point: 4.1587

>AT210404 WP_010921021.1 NZ_CP079926:3474166-3474561 [Caulobacter vibrioides]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA

Download         Length: 396 bp

>AT210404 NZ_CP104516:c1952711-1952343 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCAACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290MM32

Antitoxin

Source ID Structure
AlphaFold DB Q9A3L8

References