Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 3473973..3474561 | Replicon | chromosome |
Accession | NZ_CP079926 | ||
Organism | Caulobacter vibrioides strain CB S2B lysogen |
Toxin (Protein)
Gene name | hicA | Uniprot ID | Q9A3L9 |
Locus tag | KZH45_RS16875 | Protein ID | WP_010921020.1 |
Coordinates | 3473973..3474161 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | Q9A3L8 |
Locus tag | KZH45_RS16880 | Protein ID | WP_010921021.1 |
Coordinates | 3474166..3474561 (+) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZH45_RS16850 (KZH45_16845) | 3469857..3470876 | - | 1020 | WP_024265922.1 | amidohydrolase family protein | - |
KZH45_RS16855 (KZH45_16850) | 3471052..3472086 | + | 1035 | WP_010921016.1 | adenosine deaminase | - |
KZH45_RS16860 (KZH45_16855) | 3472097..3473065 | + | 969 | WP_010921017.1 | magnesium and cobalt transport protein CorA | - |
KZH45_RS16865 (KZH45_16860) | 3473043..3473594 | - | 552 | WP_010921018.1 | hypothetical protein | - |
KZH45_RS16870 (KZH45_16865) | 3473591..3473896 | - | 306 | WP_010921019.1 | PadR family transcriptional regulator | - |
KZH45_RS16875 (KZH45_16870) | 3473973..3474161 | + | 189 | WP_010921020.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
KZH45_RS16880 (KZH45_16875) | 3474166..3474561 | + | 396 | WP_010921021.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
KZH45_RS16885 (KZH45_16880) | 3474570..3475046 | - | 477 | WP_010921022.1 | DUF2199 domain-containing protein | - |
KZH45_RS16890 (KZH45_16885) | 3475104..3476102 | - | 999 | WP_010921023.1 | DegT/DnrJ/EryC1/StrS aminotransferase family protein | - |
KZH45_RS16895 (KZH45_16890) | 3476230..3477783 | - | 1554 | WP_010921024.1 | class I adenylate-forming enzyme family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 6984.02 Da Isoelectric Point: 11.4778
>T210404 WP_010921020.1 NZ_CP079926:3473973-3474161 [Caulobacter vibrioides]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR
Download Length: 189 bp
>T210404 NZ_CP104516:c1952253-1951876 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 13937.84 Da Isoelectric Point: 4.1587
>AT210404 WP_010921021.1 NZ_CP079926:3474166-3474561 [Caulobacter vibrioides]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA
Download Length: 396 bp
>AT210404 NZ_CP104516:c1952711-1952343 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCAACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCAACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A290MM32 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9A3L8 |