Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/- |
Location | 3414353..3414795 | Replicon | chromosome |
Accession | NZ_CP079926 | ||
Organism | Caulobacter vibrioides strain CB S2B lysogen |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0H3CB57 |
Locus tag | KZH45_RS16605 | Protein ID | WP_012640672.1 |
Coordinates | 3414520..3414795 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | P0CW75 |
Locus tag | KZH45_RS16600 | Protein ID | WP_012640671.1 |
Coordinates | 3414353..3414532 (+) | Length | 60 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZH45_RS16585 (KZH45_16580) | 3409411..3411432 | - | 2022 | WP_010920964.1 | tetratricopeptide repeat-containing sulfotransferase family protein | - |
KZH45_RS16590 (KZH45_16585) | 3411515..3412804 | - | 1290 | WP_010920965.1 | FAD-binding oxidoreductase | - |
KZH45_RS16595 (KZH45_16590) | 3412880..3414277 | - | 1398 | WP_010920966.1 | glutamine synthetase family protein | - |
KZH45_RS16600 (KZH45_16595) | 3414353..3414532 | + | 180 | WP_012640671.1 | antitoxin RelB4 | Antitoxin |
KZH45_RS16605 (KZH45_16600) | 3414520..3414795 | + | 276 | WP_012640672.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KZH45_RS16610 (KZH45_16605) | 3414798..3416201 | - | 1404 | WP_010920968.1 | aspartate aminotransferase family protein | - |
KZH45_RS16615 (KZH45_16610) | 3416219..3416968 | - | 750 | WP_012640673.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
KZH45_RS16620 (KZH45_16615) | 3416973..3418118 | - | 1146 | WP_010920970.1 | ABC transporter ATP-binding protein | - |
KZH45_RS16625 (KZH45_16620) | 3418264..3419139 | - | 876 | WP_012640674.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10141.74 Da Isoelectric Point: 11.9574
>T210403 WP_012640672.1 NZ_CP079926:3414520-3414795 [Caulobacter vibrioides]
VAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVI
GSVRHGARRPI
VAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVI
GSVRHGARRPI
Download Length: 276 bp
>T210403 NZ_CP104516:1780367-1780909 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACTCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACTCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 60 a.a. Molecular weight: 6606.17 Da Isoelectric Point: 3.9689
>AT210403 WP_012640671.1 NZ_CP079926:3414353-3414532 [Caulobacter vibrioides]
MAEPDPDIFDEDDEAILAADAEADADFEAGRTVPHERVGEWLKTLGTPHQTPPPYSWRK
MAEPDPDIFDEDDEAILAADAEADADFEAGRTVPHERVGEWLKTLGTPHQTPPPYSWRK
Download Length: 180 bp
>AT210403 NZ_CP104516:1780072-1780383 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3CB57 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | P0CW75 |