Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 3414353..3414795 Replicon chromosome
Accession NZ_CP079926
Organism Caulobacter vibrioides strain CB S2B lysogen

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3CB57
Locus tag KZH45_RS16605 Protein ID WP_012640672.1
Coordinates 3414520..3414795 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID P0CW75
Locus tag KZH45_RS16600 Protein ID WP_012640671.1
Coordinates 3414353..3414532 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH45_RS16585 (KZH45_16580) 3409411..3411432 - 2022 WP_010920964.1 tetratricopeptide repeat-containing sulfotransferase family protein -
KZH45_RS16590 (KZH45_16585) 3411515..3412804 - 1290 WP_010920965.1 FAD-binding oxidoreductase -
KZH45_RS16595 (KZH45_16590) 3412880..3414277 - 1398 WP_010920966.1 glutamine synthetase family protein -
KZH45_RS16600 (KZH45_16595) 3414353..3414532 + 180 WP_012640671.1 antitoxin RelB4 Antitoxin
KZH45_RS16605 (KZH45_16600) 3414520..3414795 + 276 WP_012640672.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZH45_RS16610 (KZH45_16605) 3414798..3416201 - 1404 WP_010920968.1 aspartate aminotransferase family protein -
KZH45_RS16615 (KZH45_16610) 3416219..3416968 - 750 WP_012640673.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
KZH45_RS16620 (KZH45_16615) 3416973..3418118 - 1146 WP_010920970.1 ABC transporter ATP-binding protein -
KZH45_RS16625 (KZH45_16620) 3418264..3419139 - 876 WP_012640674.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10141.74 Da        Isoelectric Point: 11.9574

>T210403 WP_012640672.1 NZ_CP079926:3414520-3414795 [Caulobacter vibrioides]
VAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVI
GSVRHGARRPI

Download         Length: 276 bp

>T210403 NZ_CP104516:1780367-1780909 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACTCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6606.17 Da        Isoelectric Point: 3.9689

>AT210403 WP_012640671.1 NZ_CP079926:3414353-3414532 [Caulobacter vibrioides]
MAEPDPDIFDEDDEAILAADAEADADFEAGRTVPHERVGEWLKTLGTPHQTPPPYSWRK

Download         Length: 180 bp

>AT210403 NZ_CP104516:1780072-1780383 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3CB57

Antitoxin

Source ID Structure
AlphaFold DB P0CW75

References