Detailed information of TA system TA210402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3027213..3028876
• Replicon: chromosome
• Accession: NZ_CP079926
• Organism: Caulobacter vibrioides strain CB S2B lysogen

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: Q9A4R0
• Locus tag: KZH45_RS14715
• Protein ID: WP_010920611.1
• Coordinates: 3027213..3028520 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: KZH45_RS14720
• Protein ID: WP_010920612.1
• Coordinates: 3028517..3028876 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZH45_RS14690 (KZH45_14685)	3022301..3023671	-	1371	WP_012640579.1	hypothetical protein	-
KZH45_RS14695 (KZH45_14690)	3023832..3025229	-	1398	WP_010920606.1	sensor histidine kinase	-
KZH45_RS14700 (KZH45_14695)	3025360..3026037	-	678	WP_010920607.1	response regulator transcription factor	-
KZH45_RS14705 (KZH45_14700)	3026056..3026373	-	318	WP_010920608.1	PepSY domain-containing protein	-
KZH45_RS14710 (KZH45_14705)	3026502..3027011	-	510	WP_010920609.1	hypothetical protein	-
KZH45_RS14715 (KZH45_14710)	3027213..3028520	-	1308	WP_010920611.1	type II toxin-antitoxin system HipA family toxin	Toxin
KZH45_RS14720 (KZH45_14715)	3028517..3028876	-	360	WP_010920612.1	helix-turn-helix domain-containing protein	Antitoxin
KZH45_RS14725 (KZH45_14720)	3029039..3029983	-	945	WP_012640580.1	J domain-containing protein	-
KZH45_RS14730 (KZH45_14725)	3030072..3032603	-	2532	WP_012640581.1	glycoside hydrolase/phage tail family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (170-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-67)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 47909.26 Da
• Isoelectric Point: 6.8907

>T210402 WP_010920611.1 NZ_CP079926:c3028520-3027213 [Caulobacter vibrioides]
MTTVAEVRLWGSRIGAVSLEDGAETAVFAYEPSFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLSMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWRLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFDE
VREAVMRWPTFADAAGVDERWRDQIGATVRLELRR

Nucleotide

• Length: 1308 bp

>T210402 NZ_CP104516:1746381-1746599 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13019.91 Da
• Isoelectric Point: 10.1741

>AT210402 WP_010920612.1 NZ_CP079926:c3028876-3028517 [Caulobacter vibrioides]
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK

Nucleotide

• Length: 360 bp

>AT210402 NZ_CP104516:1745981-1746355 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: Q9A4R0