Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 968731..969284 Replicon chromosome
Accession NZ_CP079926
Organism Caulobacter vibrioides strain CB S2B lysogen

Toxin (Protein)


Gene name parE Uniprot ID Q9A9T8
Locus tag KZH45_RS04545 Protein ID WP_010918758.1
Coordinates 968731..969021 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58091
Locus tag KZH45_RS04550 Protein ID WP_010918759.1
Coordinates 969018..969284 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH45_RS04515 (KZH45_04515) 964098..965288 - 1191 WP_010918752.1 erythromycin esterase family protein -
KZH45_RS04520 (KZH45_04520) 965351..965941 - 591 WP_010918753.1 AAA family ATPase -
KZH45_RS04525 (KZH45_04525) 965938..967005 - 1068 WP_012640075.1 serine hydrolase domain-containing protein -
KZH45_RS04530 (KZH45_04530) 967055..967231 - 177 WP_010918755.1 hypothetical protein -
KZH45_RS04535 (KZH45_04535) 967310..967837 - 528 WP_012640076.1 GNAT family N-acetyltransferase -
KZH45_RS04540 (KZH45_04540) 967969..968730 + 762 WP_024265642.1 MOSC domain-containing protein -
KZH45_RS04545 (KZH45_04545) 968731..969021 - 291 WP_010918758.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZH45_RS04550 (KZH45_04550) 969018..969284 - 267 WP_010918759.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KZH45_RS04555 (KZH45_04555) 969358..970227 + 870 WP_012640077.1 peptide chain release factor N(5)-glutamine methyltransferase -
KZH45_RS04560 (KZH45_04560) 970265..970489 + 225 WP_012640078.1 hypothetical protein -
KZH45_RS04565 (KZH45_04565) 970486..971598 + 1113 WP_010918761.1 DUF4167 domain-containing protein -
KZH45_RS04570 (KZH45_04570) 971766..972521 + 756 WP_010918762.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(2-81)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11057.55 Da        Isoelectric Point: 8.9111

>T210400 WP_010918758.1 NZ_CP079926:c969021-968731 [Caulobacter vibrioides]
MKPYRLSRRAKADLDDIWTYSEQRWGVEQAADYARELQATIEMIAEHPGMGQPDENLRAGYRRCASGSHVVFYRVGVRVE
IIRVLHQSMNARAHLG

Download         Length: 291 bp

>T210400 NZ_CP104516:924019-924126 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9635.57 Da        Isoelectric Point: 4.1523

>AT210400 WP_010918759.1 NZ_CP079926:c969284-969018 [Caulobacter vibrioides]
MASKNTSVVLGDHFQAFIDSQVADGRYGSASEVIRAGLRLLEENEAKLAALRAALIEGEESGFIEDFDFDAFIEERSRAS
APQGFHEE

Download         Length: 267 bp

>AT210400 NZ_CP104516:c923972-923906 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3KXE

Antitoxin

Source ID Structure
PDB 3KXE
AlphaFold DB A0A290N011

References