Detailed information of TA system TA210396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3950588..3951402
• Replicon: chromosome
• Accession: NZ_CP079924
• Organism: Escherichia sp. TC-EC600-tetX4

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: KXD89_RS19190
• Protein ID: WP_001054376.1
• Coordinates: 3950588..3950845 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: KXD89_RS19195
• Protein ID: WP_001309181.1
• Coordinates: 3950857..3951402 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXD89_RS19170 (3945876)	3945876..3946982	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
KXD89_RS19175 (3947047)	3947047..3948027	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
KXD89_RS22345 (3948137)	3948137..3948342	+	206	Protein_3753	HNH endonuclease	-
KXD89_RS19180 (3948610)	3948610..3949850	-	1241	Protein_3754	helicase YjhR	-
KXD89_RS22350 (3949966)	3949966..3950097	+	132	WP_001309182.1	hypothetical protein	-
KXD89_RS19190 (3950588)	3950588..3950845	+	258	WP_001054376.1	YjhX family toxin	Toxin
KXD89_RS19195 (3950857)	3950857..3951402	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
KXD89_RS19200 (3951458)	3951458..3952204	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
KXD89_RS19205 (3952373)	3952373..3952591	+	219	Protein_3759	hypothetical protein	-
KXD89_RS19210 (3952629)	3952629..3952745	+	117	Protein_3760	VOC family protein	-
KXD89_RS19215 (3952990)	3952990..3954111	+	1122	WP_000010829.1	M42 family metallopeptidase	-
KXD89_RS19220 (3954108)	3954108..3954386	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
KXD89_RS19225 (3954398)	3954398..3955711	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T210396 WP_001054376.1 NZ_CP079924:3950588-3950845 [Escherichia sp. TC-EC600-tetX4]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T210396 NZ_CP104516:258009-258112 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT210396 WP_001309181.1 NZ_CP079924:3950857-3951402 [Escherichia sp. TC-EC600-tetX4]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT210396 NZ_CP104516:c258150-257879 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8