210390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233271..2233797 Replicon chromosome
Accession NZ_CP079924
Organism Escherichia sp. TC-EC600-tetX4

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KXD89_RS10780 Protein ID WP_000323025.1
Coordinates 2233510..2233797 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KXD89_RS10775 Protein ID WP_000534858.1
Coordinates 2233271..2233510 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD89_RS10720 (2228298) 2228298..2229065 - 768 Protein_2095 exonuclease -
KXD89_RS10725 (2229158) 2229158..2229349 - 192 WP_001083297.1 lysis protein YdfD -
KXD89_RS10730 (2229346) 2229346..2229534 - 189 WP_000854559.1 cell division inhibition protein DicB -
KXD89_RS10735 (2230102) 2230102..2230320 - 219 WP_001171942.1 protein YdfC -
KXD89_RS22305 (2230350) 2230350..2230478 - 129 WP_000344964.1 protein YdfB -
KXD89_RS10740 (2230480) 2230480..2230635 - 156 WP_000379575.1 DUF1391 family protein -
KXD89_RS10745 (2230802) 2230802..2231209 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KXD89_RS10750 (2231293) 2231293..2231523 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
KXD89_RS10755 (2231507) 2231507..2231785 + 279 Protein_2103 hypothetical protein -
KXD89_RS10760 (2231820) 2231820..2231969 + 150 WP_011443592.1 protein YdfW -
KXD89_RS10765 (2232406) 2232406..2232738 - 333 WP_001301033.1 FlxA-like family protein -
KXD89_RS10770 (2232941) 2232941..2233246 - 306 WP_001326990.1 protein YdfV -
KXD89_RS10775 (2233271) 2233271..2233510 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KXD89_RS10780 (2233510) 2233510..2233797 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KXD89_RS10785 (2233869) 2233869..2234024 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KXD89_RS10790 (2234241) 2234241..2234492 + 252 WP_000980994.1 protein Rem -
KXD89_RS10795 (2234559) 2234559..2234837 + 279 WP_012304870.1 hypothetical protein -
KXD89_RS10800 (2234839) 2234839..2235888 + 1050 WP_001265198.1 DUF968 domain-containing protein -
KXD89_RS10805 (2235902) 2235902..2236654 + 753 WP_001047135.1 antitermination protein -
KXD89_RS10810 (2236932) 2236932..2237021 - 90 WP_120795389.1 hypothetical protein -
KXD89_RS10815 (2237076) 2237076..2237288 - 213 WP_000087756.1 cold shock-like protein CspF -
KXD89_RS10820 (2237589) 2237589..2237804 + 216 WP_000066484.1 cold shock-like protein CspB -
KXD89_RS10825 (2238168) 2238168..2238338 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KXD89_RS10830 (2238558) 2238558..2238773 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2226435..2250791 24356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T210390 WP_000323025.1 NZ_CP079924:2233510-2233797 [Escherichia sp. TC-EC600-tetX4]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T210390 NZ_CP104509:c4727909-4727802 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT210390 WP_000534858.1 NZ_CP079924:2233271-2233510 [Escherichia sp. TC-EC600-tetX4]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT210390 NZ_CP104509:4727957-4728023 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References