Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 857605..858225 Replicon chromosome
Accession NC_005810
Organism Yersinia pestis biovar Microtus str. 91001

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YP_RS04090 Protein ID WP_002208622.1
Coordinates 857605..857808 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag YP_RS04095 Protein ID WP_002218472.1
Coordinates 857857..858225 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YP_RS04065 852627..852917 + 291 WP_042659203.1 P-II family nitrogen regulator -
YP_RS04070 853005..854294 + 1290 WP_002228344.1 ammonium transporter AmtB -
YP_RS04075 854554..855414 - 861 WP_002208625.1 acyl-CoA thioesterase II -
YP_RS04080 855671..856192 + 522 WP_002208624.1 lipoprotein -
YP_RS04085 856328..856717 - 390 WP_002208623.1 MGMT family protein -
YP_RS04090 857605..857808 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
YP_RS04095 857857..858225 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
YP_RS04100 858384..858737 - 354 WP_002208619.1 hypothetical protein -
YP_RS04105 859611..859754 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YP_RS04110 859770..860030 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T21039 WP_002208622.1 NC_005810:c857808-857605 [Yersinia pestis biovar Microtus str. 91001]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T21039 NC_005810:c857808-857605 [Yersinia pestis biovar Microtus str. 91001]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT21039 WP_002218472.1 NC_005810:c858225-857857 [Yersinia pestis biovar Microtus str. 91001]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT21039 NC_005810:c858225-857857 [Yersinia pestis biovar Microtus str. 91001]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References