Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 844698..845352 Replicon chromosome
Accession NZ_CP079924
Organism Escherichia sp. TC-EC600-tetX4

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KXD89_RS04100 Protein ID WP_000244777.1
Coordinates 844945..845352 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KXD89_RS04095 Protein ID WP_000354046.1
Coordinates 844698..844964 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXD89_RS04070 (839867) 839867..840610 + 744 WP_000951964.1 SDR family oxidoreductase -
KXD89_RS04075 (840667) 840667..842100 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
KXD89_RS04080 (842145) 842145..842456 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
KXD89_RS04085 (842620) 842620..843279 + 660 WP_072647361.1 hemolysin III family protein -
KXD89_RS04090 (843475) 843475..844455 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KXD89_RS04095 (844698) 844698..844964 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KXD89_RS04100 (844945) 844945..845352 + 408 WP_000244777.1 protein YgfX Toxin
KXD89_RS04105 (845392) 845392..845913 - 522 WP_001055874.1 flavodoxin FldB -
KXD89_RS04110 (846025) 846025..846921 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KXD89_RS04115 (846946) 846946..847656 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KXD89_RS04120 (847662) 847662..849395 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T210376 WP_000244777.1 NZ_CP079924:844945-845352 [Escherichia sp. TC-EC600-tetX4]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T210376 NZ_CP104509:c2110695-2110588 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT210376 WP_000354046.1 NZ_CP079924:844698-844964 [Escherichia sp. TC-EC600-tetX4]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210376 NZ_CP104509:2110742-2110808 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References