Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1578802..1579470 Replicon chromosome
Accession NZ_CP079923
Organism Streptococcus pneumoniae strain Rx1

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag KZH43_RS07840 Protein ID WP_001132285.1
Coordinates 1579291..1579470 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag KZH43_RS07835 Protein ID WP_000961810.1
Coordinates 1578802..1579254 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH43_RS07810 (KZH43_07810) 1574692..1575435 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
KZH43_RS07815 (KZH43_07815) 1575437..1576387 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
KZH43_RS07820 (KZH43_07820) 1576525..1576953 - 429 WP_000418176.1 NUDIX hydrolase -
KZH43_RS07825 (KZH43_07825) 1576919..1578022 - 1104 WP_000719717.1 site-2 protease family protein -
KZH43_RS07830 (KZH43_07830) 1578041..1578511 - 471 WP_000257105.1 DUF3013 family protein -
KZH43_RS07835 (KZH43_07835) 1578802..1579254 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KZH43_RS07840 (KZH43_07840) 1579291..1579470 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
KZH43_RS07845 (KZH43_07845) 1579607..1579786 - 180 WP_001809903.1 hypothetical protein -
KZH43_RS07850 (KZH43_07850) 1579951..1580190 - 240 WP_000818079.1 hypothetical protein -
KZH43_RS07855 (KZH43_07855) 1580460..1581731 + 1272 WP_001113205.1 replication-associated recombination protein A -
KZH43_RS07865 (KZH43_07865) 1582278..1583597 - 1320 WP_000608887.1 glycoside hydrolase family 32 protein -
KZH43_RS07870 (KZH43_07870) 1583607..1584452 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T210372 WP_001132285.1 NZ_CP079923:c1579470-1579291 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T210372 NZ_CP104509:956973-957371 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT210372 WP_000961810.1 NZ_CP079923:c1579254-1578802 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT210372 NZ_CP104509:956677-956970 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References