Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1588716..1589384 Replicon chromosome
Accession NZ_CP079922
Organism Streptococcus pneumoniae strain R36A

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag KZB15_RS07855 Protein ID WP_001132285.1
Coordinates 1589205..1589384 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag KZB15_RS07850 Protein ID WP_000961810.1
Coordinates 1588716..1589168 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZB15_RS07825 (KZB15_07835) 1584606..1585349 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
KZB15_RS07830 (KZB15_07840) 1585351..1586301 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
KZB15_RS07835 (KZB15_07845) 1586439..1586867 - 429 WP_000418176.1 NUDIX hydrolase -
KZB15_RS07840 (KZB15_07850) 1586833..1587936 - 1104 WP_000719717.1 site-2 protease family protein -
KZB15_RS07845 (KZB15_07855) 1587955..1588425 - 471 WP_000257105.1 DUF3013 family protein -
KZB15_RS07850 (KZB15_07860) 1588716..1589168 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KZB15_RS07855 (KZB15_07865) 1589205..1589384 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
KZB15_RS07860 (KZB15_07870) 1589521..1589700 - 180 WP_001809903.1 hypothetical protein -
KZB15_RS07865 (KZB15_07875) 1589865..1590104 - 240 WP_000818079.1 hypothetical protein -
KZB15_RS07870 (KZB15_07880) 1590374..1591645 + 1272 WP_001113205.1 replication-associated recombination protein A -
KZB15_RS07880 (KZB15_07890) 1592192..1593511 - 1320 WP_000608887.1 glycoside hydrolase family 32 protein -
KZB15_RS07885 (KZB15_07895) 1593521..1594366 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T210368 WP_001132285.1 NZ_CP079922:c1589384-1589205 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T210368 NZ_CP104509:322378-322551 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT210368 WP_000961810.1 NZ_CP079922:c1589168-1588716 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT210368 NZ_CP104509:322054-322350 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References