Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1106233..1106731 Replicon chromosome
Accession NZ_CP079922
Organism Streptococcus pneumoniae strain R36A

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag KZB15_RS05390 Protein ID WP_001809704.1
Coordinates 1106233..1106487 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag KZB15_RS05395 Protein ID WP_000208080.1
Coordinates 1106489..1106731 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZB15_RS05385 (KZB15_05395) 1104287..1106158 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
KZB15_RS05390 (KZB15_05400) 1106233..1106487 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZB15_RS05395 (KZB15_05405) 1106489..1106731 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
KZB15_RS05400 (KZB15_05410) 1106822..1107631 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
KZB15_RS05405 (KZB15_05415) 1107633..1108982 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
KZB15_RS05410 (KZB15_05420) 1108975..1109679 - 705 WP_000722076.1 response regulator YycF -
KZB15_RS05415 (KZB15_05425) 1109734..1110909 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T210366 WP_001809704.1 NZ_CP079922:c1106487-1106233 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T210366 NZ_CP104506:4717-4998 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT210366 WP_000208080.1 NZ_CP079922:c1106731-1106489 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT210366 NZ_CP104506:4476-4727 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References